MEGA-ROX The World's Largest ICU Study

Original Wellington Research

Oxygen in Critical Care
MEGAROX

The SPLIT Trial JAMA 2015

Original Wellington Research

Saline vs Plasma-Lyte 148
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Original Medical & Nursing Research from Wellington ICU

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The ANZICS CTG World-leading Australasian Research

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Wellington Investigator Led Multicentre Randomised Controlled Trials

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Publications From Wellington ICU

Authors working in Wellington ICU at the time of publication are listed in bold.
Most recent publications are listed first and are grouped by publication date.
Wellington ICU has also participated in many ANZICS CTG trials, with our medical specialists acting as co-investigators. These are also listed below.

Please select the relevant year to expand. Number of publications in parentheses.

2024 (22)
Young P, Cook D, Deane A. Editorial - preventing stress ulcer bleeding. Intensive Care Med. 2024 Oct.
Taccone F, Cariou A, Zorzi S, Friberg H, Jakobsen J, Nordberg P, Robba C, Belohlavek J, Hovdenes J, Haenggi M, Aneman A, Grejs A, Keeble T, Annons F, Young P, Wise M, Cronberg T, Lilja G, Nielsen N, Dankiewicz J. Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm - a secondary analysis of the TTM-2 study. Crit Care 28, 335 (2024)
Battaglini D , Schiavetti I, Ball L, Jakobsen JC, Lilja G, Friberg H, Wendel-Garcia PD, Young P, Eastwood G, Chew M, Unden J, Thomas M, Joannidis M Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Martin A, Solar M, Taccone FS, Dankiewicz J, Nielsen N, Grejs AM, Wise M, Hängghi M, Smid O, Patroniti N, Robba C. Association between early airway intervention in the pre-hospital setting and outcomes in out of hospital cardiac arrest patients: A post-hoc analysis of the Target Temperature Management-2 (TTM2) trial. Resuscitation. 2024 Oct. 203
Young P. Editorial: Less is best for oxygen therapy in adults in the intensive care unit with severe hypoxaemia due to COVID-19. Intensive Care Med. 2024 Sep.
Chapple L, Nuts A, O'Connor S, Williams P, Hurford S, Young P, Hammond N, Knowles S, Chapman M, Peaks S. The TARGET Investigators. Australian Crit Care. 2024 Aug
Frei D, Young P, Myles P. Oxygen Therapy during Surgery: Decisions Need Reliable Data. Anesthesiology. 2024 Sep. 141;437-439
Shawler L, Deane A, Litton E, Ankara's M, Wibrow B, Barge D, Golden J, Hammond N, Saxena M, Young P, Ventkatesh B, Finnis M, Ali Abdelhamid Y. A multicentre point prevalence study of nocturnal hours awake and enteral pharmacological sleep aids in patients admitted to Australian and New Zealand intensive care units. Crit Care Resusc. 2024 Jul
Kirton L, Sol Cruz R, Navarra L, Eathorne A, Cook J, Beasley R, Young P. Effect of automated titration of oxygen on time spent in a prescribed oxygen saturation range in adults in the ICU after cardiac surgery. Crit Care Resusc. 2024 Jun (26)2;64-70
Sivapalan P, Ellekajaer K, Perner A, Møller M, Granholm A, Grønningsæter L, Ostermann M, Mac Sweeney R, Cronhjort M, Hästbacka J, Pfortmueller C, De Waele J, Nalos M, Jovaisa T, Blaser A, Cecconi M, Ergan B, Al-Fares A, Young P, Szceklik W, Keus E, Alshamsi F, Shanna A, Sigurdsson M, Fujii T, Arabi Y, Meyhoff T. Preferences for albumin use in adult intensive care unit patients with shock: An international survey. Acta Anaesthesiol Scand. 2024; 1-10
Young P, Al-Fares A, Aryal D, Arabi Y, Ashraf M, Bagshaw S, Beane A, de Oliveira Manoel A, Dullawe L, Fazla F, Fujii T, Haifa R, Hasan M, Hodgson C, Hunt A, Lawrence C, Maia I, Mackle D, Monti G, Nichol A, Olatunji S, Patadia S, Rashan A, Rashan S, Kosza J, for the Mega-ROX management committee. Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults in the intensive care unit with suspected hypoxic ischaemic encephalopathy following a cardiac arrest (Mega-ROX HIE). Crit Care Resusc. 2024 Jun
Young P, Bailey M. Outcomes for Pacific and European patients admitted to New Zealand intensive care units from 2009 to 2018. Crit Care Resusc. 2024 Jun
Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, Hardie M, Heels-Ansdell D, Alhazzani W, Marshall J, Muscedere J, Myburgh J, English S, Arabi YM, Ostermann M, Knowles S, Hammond N, Byrne KM, Chapman M, Venkatesh B, Young P, Rajbhandari D, Poole A, Al-Fares A, Reis G, Johnson D, Iqbal M, Hall R, Meade M, Hand L, Duan E, Clarke F, Dionne JC, Tsang JLY, Rochwerg B, Karachi T, Lamontagne F, D'Aragon F, St Arnaud C, Reeve B, Geagea A, Niven D, Vazquez-Grande G, Zarychanski R, Ovakim D, Wood G, Burns KEA, Goffi A, Wilcox ME, Henderson W, Forrest D, Fowler R, Adhikari NKJ, Ball I, Mele T, Binnie A, Trop S, Mehta S, Morgan I, Loubani O, Vanstone M, Fiest K, Charbonney E, Cavayas YA, Archambault P, Rewa OG, Lau V, Kristof AS, Khwaja K, Williamson D, Kanji S, Sy E, Dennis B, Reynolds S, Marquis F, Lellouche F, Rahman A, Hosek P, Barletta JF, Cirrone R, Tutschka M, Xie F, Billot L, Thabane L, Finfer S; REVISE Investigators. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. 2024 Jun 14
Wang Y, Parpia S, Ge L, Heels-Ansdell D, Lai H, Esfahani MA, Pan B, Alhazzani W, Schandelmaier S, Lauzier F, Arabi Y, Barletta J, Deane A, Finfer S, Williamson D, Kanji S, Møller MH, Perner A, Krag M, Young PJ, Dionne JC, Hammond N, Ye Z, Ibrahim Q, Cook D. Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding - An Updated Meta-Analysis. NEJM Evid. 2024 Jun 14:EVIDoa2400134
Betteridge T, Finnis M, Cohen J, Delaney A, Young P, Udy A, for the PROMOTE-SAH Investigators. Blood Pressure Management Goals in Critically Ill Aneurysmal Subarachnoid Hemorrhage Patients in Australia and New Zealand. JJ Neurosurg Anesthesiol 2024;36:237–243)
Neto A, Bailey M, Seller D, Agil A, Bellomo R, Brickell K, Broadley T, Buhr H, Gabbe B, Gould D, Harrold M, Higgins A, Hurford S, Iwashyna T, Nichol A, Presneill J, Schaller S, Sivasuthan J, Tipping C, Poole A, Parke R, Bradley S, Webb S, Young P, Hodgson C. Impact of High Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial. Am J Resp Crit Care Med. May 2024.
Martin D, Shahid T, Gould D, Richards-Belle A, Doidge J, Camsooksai J, Charles W, Davey M, Johnson A, Garrett R, Grocott M, Jones J, Lampro L, Miller L, O'Driscoll BR, Rostron A, Sadique Z, Szakmany T, Young P, Rowan K, Harrison D, Mouncey P. Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care: Protocol for the UK-ROX trial. JICS. Apr 2024.
Kirton L, Sol Cruz R, Navarra L, Eathorne A, Cook J, Beasley R, Young P. Effect of automated titration of oxygen on time spent in a prescribed oxygen saturation range in adults in the ICU after cardiac surgery. Crit Care Resusc. Mar 2024.
Buell K, Spicer A, Casey J, Seltz K, QIan E, Graham Linck E, Self W, Rice T, Sinha P, Young P, Semler M, Churpek M. Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults. JAMA. Mar 2024
Opgenorth D, Duquesne D, Tyre L, Auld R, Crowder K, Gilchrist P, Young P, Bagshaw S. Public perception of participation in low-risk clinical trials in critical care using waived consent: a Canadian national survey. Can J Anesthetiser. Mar 2024
Hills T, Delaney A, Young P. Correspondence: Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia. NEJM. Mar 2024;390:769-770
Frei D, Moore M, Bailey M, Beasley R, Campbell D, Leslie K, Myles P, Short T, Young P. Associations between the intraoperative fraction of inspired intraoperative oxygen administration and days alive and out of hospital after surgery. BJA Open. Vol 9. Mar 2024. 100253
Pickkers P, Angus D, Bass K, Bellomo R, van den Berg E, Bernholz J, Bestle M, Doi K, Doig C, Ferrer R, Francois B, Gammelager H, Goettrup Pedersen U, Hoste E, Iversen S, Joannidis M, Kellum J, Liu K, Meersch M, Mehta R, Millingon S, Murray P, Nichol A, Ostermann M, Bettina V, Solling C, Winkel M, Young P, Zarbock A on behalf of the REVIVAL investigators. Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL). Intensive Care Medicine. Jan 2024.
2023 (37)
Taccone F, Dankiewicz J, Cariou A, Lilja G, Asfar P, Belohlavek J, Boulain T, Colin G, Cronberg T, Frat J-P, Friberg H, Grejs A, Grillet G, Girardi P, Haenggi M, Hovdenes J, Jakobsen J, Levin H, Merdji H, Nijimi H, Pelosi P, Rylander C, Saxena M, Thomas M, Young P, Wise M, Nielsen N, Lascarrou J-B. Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm - a meta-analysis. JAMA Neurology 2023 Dec
D Heels-Ansdel, L Billot, LThabane, W Alhazzani, A Deane, G Guyatt, S Finfer, F Lauzier, J Myburgh, P Young, Y Arabi, J Marshall, S English, J Muscedere, M Ostermann, B Venkatesh, N Zytaruk, M Hardie, N Hammond, S Knowles, L Saunders, A Poole, A Al-Fares, F, Die, R Hall, D Cook. REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial. Trials 24, 796
Zampieri F, Cavalcanti A, Di Tanna G, Damiani L, Hammond N, Machado F, Micallef S, Myburgh J, Ramanan M, Venkatesh B, Rice T, Semler M, Young P, Finfer S. Balanced crystalloids versus saline for critically ill patients (BEST-Living): a systematic review and individual patient data meta-analysis.
The Lancet. 2023 Nov.
Golding D, Wai Chan T, Orozov N, Young P. Masking of an intravenous preparation of ceftriaxone for use in clinical trials: A technical report. Crit Care Resusc. 2023 Nov.
Blackburne W, Young P. Perceptions of intensive care triage in Australia and New Zealand in 2009 and 2023. Crit Care Resusc. 2023 Nov.
Jayasimhan D, Matthew M. Corticosteroids in adults with acute respiratory distress syndrome and severe pneumonia. BJA Education, 23(12): 456-463 (2023)
Young P, Delaney A, Hills T. Ventilator-associated pneumonia: A problematic outcome for clinical trials. Crit Care Resusc. 2023 Nov
Deane A, Alhazzani W, Guyana G, Finfer S, Marshall J, Myburgh J, Zytaruk N, Hardie M, Saunders L, Knowles S, Lauzier F, Chapman M, English S, Muscedere J, Arabi Y, Ostermann M, Venkatesh B, Young P, Thabane L, Billot L, Heels-Ansdell D, Al-Fares A, Hammond N, Hall R, Rajbhandari D, Poole A, Johnson D, Iqbal M, Reis G, Xie F, Cook D. REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU: a randomised trial protocol. BMJ Open 2023;13:e075588
Young P, Devaux A, Li Q, Billot L, Davis J, Delaney A, Finfer S, Hammond N, Micallef S, Septet I, Venkatesh B, Myburgh J on behalf of SuDDICU. Selective digestive tract decontamination in critically ill adults with acute brain injuries: a post hoc analysis of a randomized clinical trial. ICM 2023 Nov.
Bellomo R, Ronco C, Kellum J, Reis T, Forni L, Young P, Psirides A et al. How renal is the kidney? The Lancet 2023 Oct. 402 (10412):1527
Summers M, Chapple L, Bellomo R, Chapman M, Ferrie S, Finnis M, French C, Hurford S, Kakao N, Karahalios A, Maiden M, O'Connor S, Peake S, Presneill J, Ridley E, Tran-Duy A, Williams P, Young P, Zaloumis S, Deane A. Study protocol for TARGET protein: The effect of augmented administration of enteral protein to critically ill adults on clinical outcomes: A cluster randomised, cross-sectional, double cross-over, clinical trial. Crit Care Resusc 2023 Sep. 147-154
Sutton L, Bell E, Every-Pallmer S, Weatherall M, Skirrow P. Survivorship outcomes for critically ill patients in Australia and New Zealand: A scoping review. Australian Crit Care 2023 Sep.
Jones D, Orson J, Psirides A, Pilcher D. Potential metrics for rapid response systems in Australia and New Zealand. Crit Care Resus 2023 Aug.
D Frei, R Beasley, D Campbell, A Forbes, K Leslie, D Mackle, C Martin, A Merry, M Moore, P Myles, L Ruawa-Hamilton, T Short, P Young. A vanguard randomised feasibility trial comparing three regimens of peri-operative oxygen therapy on recovery after major surgery. Anaesthesia 2023 August 02.
Young P, Hodgson C, Mackle D, Mather A, Beasley R, Bellomo R, Bernard S, Brickell K, Deane A, Eastwood G, Finfer S, Higgins A, Hunt A, Lawrence C, Linke N, Litton E, McDonald C, Moore J, Nichol A, Olatunji S, Parke R, Peake S, Secombe P, Seppelt I, Turner A, Tranapi T, Udy A, Kasza J. Protocol summary and statistical analysis plan for the low oxygen intervention for cardiac arrest injury limitation (LOGICAL) trial. Crit Care Resist. 2023 July 26.
Betteridge T, Finnis M, Cohen J, Delaney A, Young P, Udy A, for the PROMOTE-SAH investigators. Blood Pressure Management Goals in Critically Ill Aneurysmal Subarachnoid Hemorrhage Patients in Australia and New Zealand. Journal Neurosurgical Anesthesiology. 2023 July 13.
Psirides A, Mohan C. Correspondence - Comparison of the Aotearoa New Zealand Early Warning Score and National Early Warning Score to predict adverse inpatient events in a vital sign dataset. Anaesthesia. 2023 July
Gruen R, Mitra B, Bernard S, McArthur C, Burns B, Gartner D, Maegele M, Cameron P, Dicker B, Forbes A, Hurford S, Martin C, Mazut S, Medcalf R, Murray L, Myles P, Ng S, Pitt V, Rashford S, Reade M, Swain A, Trapani T, Young P. Prehospital Tranexamic Acid for Severe Trauma. NEJM. 2023 June
Serpa Neto A, Fujii T, McNamara M, Moore J, Young P, Peake S, Bailey M, Hodgson C, Higgins A, See E, Secombe P, Campbell L, Young M, Maeda M, Pilcher D, Nichol A, Deane A, Licari E, White K, French C, Shehabi Y, Cross A, Maiden M, Kadam U, El Khawas K, Cooper J, Bellomo R, Udy A. Sodium Bicarbonate for Metabolic Acidosis in the ICU - Results of a Pilot Randomized Double-Blind Clinical Trial. Crit Care Med. 2023 June.
Jayasimhan D, Chieng J, Kolbe J, Sidebotham D. Dead-Space Ventilation Indices and Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Crit Care Med. 2023 May
Young P. Oxygen therapy targets in post cardiac arrest patients with hypoxic respiratory failure. Resuscitation. 2023 May.
Young P, Al-Fares A, Aryal D, Arabi Y, Ashraf M, Bagshaw S, Beane A, de Oliveira Manoel A, Dullawe L, Fazla F, Fujii T, Haniffa R, Hodgson C, Hunt A, Vijayaraghavan B, Landoni G, Lawrence C, Maia I, Mackle D, Mazlan M, Nichol A, Olatunji S, Rashan A, Rashan S, Kasza J, for the Mega-ROX management committee, ANZICS CTG, the Critical Care Asia & Africa Network, the Irish Critical Care-Clinical Trials Group. Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with sepsis in the intensive care unit (Mega-ROX Sepsis). Crit Care Resus. 2023 May
Young P, Al-Fares A, Aryal D, Arabi Y, Ashraf M, Bagshaw S, Mat-Nor M, Beane A, Borghi G, de Oliveira Male A, Dullawe L, Fazla F, Fujii T, Haniffa R, Hodgson C, Hunt A, Lawrence C, Mackle D, Mangal K, Nichol A, Olatunji S, Rashan A, Rashan S, Tomazini B, Kasza J, for the Mega-ROX management committee, ANZICS CTG, Brazilian Research in Intensive Care Network, the Critical Care Asia & Africa Network, the Irish Critical Care-Clinical Trials Group. Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with nonhypoxic ischaemic acute brain injuries and conditions in the intensive care unit (Mega-ROX Brains). Crit Care Resus. 2023 (5);1:53-59
Mekhail A, Young P, Mekhail A-M, Tinawi G, Haran C, Clayton N, Galvin S. Stress Ulcer Prophylaxis in Cardiac Surgery: A Retrospective Cohort Study to Analyze the Effects of SUP Cessation. Journal Intensive Care Medicine. April 2023.
Wetterslev M, Møller H, Granholm A, Hassager C, Haase N, Lange T, Myatra S, Hästbacka J, Arabi Y, Shen J, Cronhjort M, Lindqvist E, Aneman A, Young P, Szczeklik W, Siegemund M, Koster T, Aslam T, Bestle M, Girkov M, Kalvit K, Mohanty R, Mascarenhas J, Pattnaik M, Vergis S, Haranath S, Shah M, Joshi Z, Wilkman E, Reinikainen M, Lehto P, Jalkanen V, Pulkkinen A, An Y, Wang G, Huang L, Huang B, Liu W, Gao H, Dou L, Li S, Yang W, Tegnell E, Knight A, Czuczwar M, Czarnik T, Perner A; and the AFIB-ICU Collaborators. Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study. Crit Care Med. April 2023.
REMAP-CAP Investigators. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19. A Randomized Clinical Trial. JAMA 2023;329(14):1183-1196
Pickkers P, Angus D, Arend J, Bellomo R, vanden Berg E, Bernholz J, Bestle M, Broglio K, Carlsen J, Doig C, Ferrer R, Joannidis M, Francois B, Doi K, Kellum J, Laterre P-F, Liu K, Mehta R, Murray P, Ostermann M, Pettilla V, Richards S, Young P, Zarbock A, Kjølbye A. Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury. BMJ Open 2023;13:e065613
Bunch J, Jones D, Psirides A. Are we deskilling or reskilling our hospital ward clinicians? Intern Med J 2023 April
Mohan C, Entezami P, John S, Hewitt J, Sylevych V, Psirides A. Comparison of the Aotearoa New Zealand Early Warning Score and National Early Warning Score to predict adverse inpatient events in a vital sign dataset. Anaesthesia 2023 Mar 29
Berry-Kilgour N, Paulin J, Psirides A, Pegg T. A survey of hospital practitioners: common understanding of CPR definition and outcomes. Intern Med J. 2023 Mar 6
Best A, Harvey C, Minton C. Experiences of families of prolonged critical illness survivors that are discharged home -an integrative review of the literature. Nurs Crit Care 2023;1-12
Monroe E, Hyzy R, Semler M, Shankar-Hari M, Young P, Zampieri F, Prescott H. Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review. American Journal Resp Crit Care Med. 2023 Feb.
Paton M, Chan S, Tipping C, Stratton A, Serpa Neto A, Lane R, Young P, Romero L, Broadley T, Hodgson C. The effect of mobilisation at 6 months after critical illness - meta-analysis. NEJM Evil 2023;2(2)
Frei D, Beasley R, Campbell D, Leslie K, Merry A, Moore M, Myles P, Ruawai-Hamilton L, Short T, Sibanda N, Young P. Perioperative oxygen administration in patients undergoing major non-cardiac surgery under general anaesthesia in Australia and New Zealand. Anaesthesia and Intensive Care. 2023 Jan.
REMAP-CAP Writing Committee. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA. 2023;329(1):39-51
Sherrer M, Franklin A, Kimatian S, Black I, Tsai M. The Icarus Paradox and the Future of Anaesthesiology. Anesth Analg. 2023 Jan 1;136(1):185-189
Best A, Harvey C, Minton C. A protocol for exploring patient's and support people's experiences after prolonged critical illness. Nurs Crit Care 2023 Jan
2022 (34)
Paton M, Chan S, Tipping C, Stratton A, Serpa Neto A, Lane R, Young P, Romero L, Broadley T, Hodgson C. The Effect of Mobilization at 6 Months after Critical Illness — Meta-Analysis. NEJM Evidence 2022:2(2)
Simpson R, Dankiewicz J, Karamasis G, Pelosi P, Haenggi M, Young P, Jakobsen J, Bannard-Smith J, Wendel-Garcia P, Taccone F, Nordberg P, Wise M, Grejs A, Lilla G, Olsen R, Cariou A, Lascarrou JB, Saxena M, Hovdenes J, Thomas M, Friberg H, Davies J, Nielsen N, Keeble T. Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial. Crit Care. 2022. 26:356
Klick C, Black I, Tsai M. Critical Care: Regionalization is Necessary. Anesth Analg. 2022 Nov;135(5):e39-e40
Robba C, Badenes R, Battaglini D, Ball L, Sanfilippo F, Brunetti I, Jakobsen JC, Lilja G, Friberg H, Wendel-Garcia P, Young P, Eastwood G, Chew M, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Martin A, Solar M, Taccone F, Dankiewicz J, Nielsen N, Grejs A, Ebner F, Pelosi P & TTM 2 Trial collaborators. Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. Critical Care. 2022 Oct. 26(323)
Hodgson C, Bailey M, Bellomo R, Brickell K, Broadley T, Buhr H, Gabbe B, Gould D, Harrold M, Higgins A, Hurford S, Iwashyna T, Neto AS, Nichol A, Presneill J, Schaller S, Sivasuthan J, Tipping C, Webb S, Young P. The TEAM Study Investigators and the ANZICS Clinical Trials Group. Early active mobilisation during mechanical ventilation in the ICU. NEJM. 2022 Oct.
Myburgh J, Septet I, Goodman F, Billot L, Correa M, Davis J, Gordon A, Hammond N, Iredell J, Li Q, Micallef S, Miller J, Mysore J, Taylor C, Young P, Cuthbertson B, Finfer S. The SUDDICU Investigators for the ANZICS Clinical Trials Group. Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation A Randomized Clinical Trial. JAMA. 2022 Oct.
Zampieri F, Cavalcanti A, Di Tanna G, Damiani L, Hammond N, Machado F, Micallef S, Myburgh J, Ramanan M, Rice T, Semler M, Young P, Finfer S. Statistical Analysis Plan for Balanced versus Saline trialists living systematic review individual patient and aggregated data meta-analysis of randomized controlled trials (BEST-Living Study). medRxiv Preprint. 2022 Oct.
Mistry R, Moore J. Management of blunt thoracic trauma. British Journal of Anaesthesia Education. 2022 Oct.
Slater A, Beca J, Croston E, McEniery J, Millar J, Norton L, Numa A, Schell D, Secombe P, Straney L, Young P, Yung M, Gabbe B, Shann F. Association Between Centralization and Outcome for Children Admitted to Intensive Care in Australia and New Zealand: A Population-Based Cohort Study. Paid Crit Care Med. 2022 Aug.
Young P, Lamontagne F, Fujii T. Vitamin C in sepsis. Intensive Care Med. 2022 Aug.
Ross J, Ramsay D, Sutton-Smith L, Willink R, Moore J. Residual neuromuscular blockade in the ICU: a prospective observational study and national survey. Anaesthesia. 2022 Jul.
Schlapbach L,, Gibbons K, Horton S, Johnson K, Long D, Buckley D, Erickson S, Festa M, d’Udekem Y, Alphonso N, Winlaw D, Delzoppo, C, van Loon K, Jones M, Young P, Butt W, Schibler A. For the NITRIC Study Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG), and the ANZICS Paediatric Study Group (PSG). Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial. JAMA. 2022 Jun
Bruce P, Ainscough K, Hatter L, Braithwaite I, Berry L, Fitzgerald M, Hills T, Brickell K, Cosgrave D, Semprini A, Morpeth S, Berry S, Doran P, Young P, Beasley R, Nichol A. Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analyses. Trials. 2022. 23:534
Robba C, Badenes R, Battaglini D, Ball L, Brunetti I, Jakobsen J, Lilja G, Friberg H, Wendel-Garcia P, Young P, Eastwood G, Chew M, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Annborn M, Solar M, Taccone F, Dankiewicz J, Nielsen N, Pelosi P on behalf of the TTM2 Trial Collaborators. Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial. Intensive Care Med. 2022 Jun
Holgersson J, Meyer M, Dankiewicz J, Lilka G, Ullen S, Hassager C, Cronberg T, Wise M, Belohlavek J, Hovdenes J, Pelosi P, Erlinge D, Schrag C, Smid O, Brunetti I, Rylander C, Young P, Saxena M, Aneman A, Cariou A, Callaway C, Eastwood G, Haenggi M, Joannidis M, Keeble T, Kirkegaard H, Leithner C, Levin H, Nichol A, Morgan M, Nordberg P, Oddo M, Storm C, Taccone F, Thomas M, Bro-Jeppesen J, Horn J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Friberg H, Nielsen N, Jakobsen J. Hypotemric versus normothermic temperature control after cardiac arrest. NEJM Evidence. 2022 Jun.
Lamontagne F, Masse M-H, Menard J, Sprague S, Pinto R, Heyland D, Cook D, Battista M-C, Day A, Guyatt G, Kanji S, Parke R, McGuinness, S, Vijayaraghavan B-K, Annane D, Arabi Y, Bolduc B, Marinoff N, Rochwerg B, Millen T, O'Meade M, Hand L, Watpool I, Porteous R, Young P, D'Aragon F, Belley-Cote E, Carbonneau E, Clarke F, Maslove D, Hunt M, Chasse M, Lebrasseur M, Lauzier F, Mehta S, Quiroz-Martinez H, Rewa O, Charbonney E, Seely A, Kutsogiannis D, LeBlanc R, Mekontso-Dessao A, Mele T, Turgeon A, Wood D, Kohli S, Shahin J, Twardowski P, Adhikari N, for the LOVIT Investigators. Intravenous VItamin C in Adults with Sepsis in the Intensive Care Unit. NEJM. 2022 Jun
Young P. Recent data and the French guidelines for choice of intravenous fluid for vascular filling. Anaesthesia Crit Care & Pain Med. 2022 Jun;41(3)
Young P, Arabi Y, Bagshaw S, Bellomo R, Fujii T, Haniffa R, Hodgson C, Kumar B, Vijayaraghavan T, Litton E, Mackle D, Nichol A, Kasza J, The Mega-ROX Management Committee. Protocol and statistical analysis plan for the mega randomised registry trial research program comparing conservative versus liberal oxygenation targets in adults receiving unplanned invasive mechanical ventilation in the ICU (Mega-ROX). Crit Care Resusc 2022;24(2):137-49
Zampieri F, Cavalcanti A, Di Tanna GL, Damiani L, Hammond N, Machado F, Micallef S, Myburgh J, Rice T, Semler M, Young P, Finfer S. Protocol for balanced versus saline trialists: living systematic review and individual patient data meta-analysis of randomised controlled trials (BEST-Living study). Crit Care Resusc 2022;24(2):128-36
Young P, Mackle D, Hodgson C, Bellomo R, Bailey M, Beasley R, Deane A, Eastwood G, Finfer S, Freebairn R, King V, Linke N, Litton E, McArthur C, McGuinness S, Panwar R, ICU-ROX Investigators. Conservative or liberal oxygen therapy for mechanically ventilated adults with acute brain pathologies: A post-hoc subgroup analysis. Journal Crit Care. 2022 Oct.
Poole A, Finnis M, Anstey J, Bellomo R, Bihari S, Birardar V, Doherty S, Eastwood G, Finfer S, French C, Heller S, Horowitz M, Kar P, Kruger P, Maiden M, Mårtensson J, McArthur C, McGuinness S, Secombe P, Tobin A, Udy A, Young P, Deane A for the LUCID STudy Investigators and ANZICS CTG. The Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial. Am Journ Resp and Crit Care Med. 2022 May.
Young P, Hodgson C, Rasmussen B. Oxygen Targets. Intensive Care Med. 2022 May.
Adhikari N, Pinto R, Day A, Masse M-H, Ménard J, Sprague S, Annane D, Arabi Y, Battista M-C, Cohen D, Cook D, Guyatt G, Heyland D, Kanji S, McGuinness S, Parke R, Vijayaraghavan B, Charbonney E, Chassé M, Del Sorbo L, Kutsogiannis D, Lauzier F, Leblanc R, Maslove D, Mehta S, Dessap A, Mele T, Rochwerg B, Rewa O, Shahin J, Twardowski P, Young P, Lamontagne F. Lessening Organ dysfunction with VITamin C (LOVIT): statistical analysis plan. JMIR Research Protocols. 2022 Apr.
REMAP-CAP Writing Committee. Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19
A Randomized Clinical Trial. JAMA. 2022;327(13):1247-1259
Hays L, Udy A, Adamides A, Anstey J, Bailey M, Bellapart J, Byrne K, Cheng A, Cooper J, Drummond K, Haenggi M, Jakob S, Higgins A, Lewis P, Hunn M, McNamara R, Menon D, Murray L, Reddi B, Trapani T, Vallance S, Young P, Diaz-Arrastia R, Shutter L, Murray P, Curley G, Nichol A. Effects of brain tissue oxygen (PbtO2) guided management on patient outcomes following severe traumatic brain injury: A systematic review and meta-analysis. Journal Clin Neurosc. 2022;99:349-358
Sutton L, Bell E, Every-Palmer S, Weatherall M, Skirrow P. Survivorship of Patients after Long Intensive Care Stay With Exploration and Experience in a New Zealand Cohort (SPLIT ENZ):Protocol for a Mixed Methods Study. JMIR. 2022;11(3)
Serpa Neto A, Fujii T, Moore J, Young P, Peake S, Bailey M, Hodgson C, Higgins A, See E, Secombe P, Russ V, Campbell L, Young M, Maeda M, Pilcher D, Cooper J, Udy A. Clinical outcomes of Indigenous Australians and New Zealand Māori with metabolic acidosis and acidaemia. Crit Care Resist. 2022;24(1):14-9
Roba C, Nielsen N, Dankiewicz J, Badenes R, Battaglini D, Ball L, Brunetti I, David W-G, Young P, Eastwood G, Chew M, Jakobsen J, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Lilja G, Hammond N, Saxena M, Martin A, Solar M, Taccone F, Friberg H, Pelosi P. Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial. BMJ Open. 2022
Van Diepen S, Coulson T, Wang X, Opgenorth D, Zuege D, Harris J, Agyemang M, Niven D, Bellomo R, Wright S, Young P, Bagshaw S, for the PEPTIC study investigators and the ANZICS Clinical Trials Group. Efficacy and safety of proton pump inhibitors versus histamine-2 receptor blockers in the cardiac surgical population: insights from the PEPTIC trial. European Journal Cardio-Thoracic Surgery. 2022 Feb
Barnett A, Beasley R, Buchan C, Chien J, Farah C, King G, McDonald C, Miller B, Muncie M, Psirides A, Reid L, Roberts M, Smallwood N, Smith S. Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’. Respirology. 2022 Feb
Darvall J, Bellomo R, Bailey M, Young P, Rockwood K, Pilcher D. Impact of frailty on persistent critical illness: a population-based cohort study. Intensive Care Medicine. 2022 Feb
Finfer S, Zampieri F, Young P. Crystalloid Composition and Rate of Fluid Administration When Resuscitating Patients in the Intensive Care Unit. JAMA. 2021;326 (24):2531-2532
Hammond N, Zampieri F, Di Tanna G, Garside T, Adigbli D, Cavalcanti A, Machado F, Micallef S, Myburgh J, Ramanan M, Rice T, Semler M, Young P, Venkatesh B, Finfer S, Delaney A. Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis. NEJM Evidence. 2022 Jan
Finfer S, Micallef S, Hammond N, Navarra L, Bellomo R, Billot L, Delaney A, Gallagher M, Gantas D, Li Q, Mackle D, Mysore J, Saxena M, Taylor C, Young P, Myburgh J for PLUS Study Investigators & ANZICS CTG. Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. NEJM. 2022 Jan
2021 (38)
  • Singer M, Young P, Laffey J, Asfar P, Taccone F, Skrifvars M, Meyhoff C, Radermacher P. Dangers of hyperoxia. Critical Care. 2021 Dec 19;25:440
  • Sutton-Smith L, Weatherall M, Bell E, Every-Palmer S, Skirraw P. What are the long-term outcomes for New Zealand survivors of critical illness? NZMJ. 2021 Dec 17;134:1547(17)
  • Wetterslev M, Hylander Møller M, Granholm A, Hassager C, Haase N, Naz Aslam T, Shen J, Young P, Aneman A, Hästbacka J, Siegemund M, Cronhjort M, Lindqvist E, Myatra S, Kalvit K, Arabi Y, Szczeklik W, Sigurdsson M, Balik M, Keus F, Perner A, the AFIB-ICU collaborators. Management of acute atrial fibrillation in the intensive care unit: An international survey. Acta Anaesth Scand 2021 Dec.
  • Moore J, Bellomo R, Bailey M, Hodgson C, Young P, for the ANZICS CORE Management Committee. Characteristics and outcomes of adults admitted to New Zealand ICUs following a cardiac arrest by ethnicity: a brief report. Crit Care Resusc 2021;23(4):418-422
  • Murthy T, Bellomo R, Chapman M, Deane A, Ferrie S, Finnis M, Hurford S, O'Connor S, Peake S, Summers M, Williams P, Young P, Chapple L, for the TARGET Protein Management Committee. Protein delivery in mechanically ventilated adults in Australia and New Zealand: current practice. Crit Care Resist. 2021;23(4):386-393
  • Scquizzato T, Young P, Landoni G, Maraca L, Zangrillo L. Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno’s paradox of the Tortoise and Achilles? Crit Care. 2021;25:409
  • Granholm A, Alhazzani W, Derde L, Angus D, Zampieri F, Hammond N, Mac Sweeney R, Myatra S, Azoulay E, Rowan K, Young P, Perner A, Hylander Møller M. Randomised clinical trials in critical care: past, present and future. Intensive Care med. 2021.
  • Costa-Pinto R, Yong Z, Yanase F, Young C, Brown A, Udy A, Young P, Eastwood G, Bellomo R. A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study. Journ Crit Care. 2022;67:166-171
  • Young P, Psirides A, Streat S. New Zealand's staffed ICU bed capacity and COVID-19 surge capacity. NZMJ. 2021 Nov 12;134:1545(8-10)
  • Young P. Intravenous fluid therapy in the intensive care unit: back to BaSICS? Anaesth Crit Care Pain Med. 2021 Nov 5;100979
  • Fujii T, Salanti G, Belletti A, Bellomo R, Carr A, Furukawa T, Luethi N, Luo Y, Putzu A, Sartini C, Tsujimoto Y, Udy A, Yanase F, Young P. Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis. Intensive Care Med. 2021 Nov 09.
  • Young P, De Jong A. New Insights into the Comparative Effectiveness of Fentanyl and Morphine Infusions in Intensive Care Unit Patients. Am Journalist Resp Crit Care Med. 2021 Oct 13.
  • Gladwin B, Young P. Methylene Blue for Vasoplegic Syndrome Post Cardiac Surgery. ICU Management & Practice. 2021; 21(5)248-249
  • Young P, Bailey M, Bellomo R. An Update on Temperature Management Following Cardiac Arrest in Australian and New Zealand ICUs. Crit Care Med. 2021 Oct; 49(10)1040-1042
  • Boyle A, Holmes D, Hackett J, Gilliland S, McCloskey M, O'Kane C, Young P, Di Gangi S, McAuley D. Hyperoxaemia and hypoxaemia are associated with harm in patients with ARDS. BMC Pulm Med 21; 285 (2021).
  • Hammond N, Zampieri F, Garside T, Adigbli D, Di Tanna G, Cavalcanti A, Machado F, Micallef S, Myburgh J, Ramanan M, Rice T, Semler M, Young P, Venkatesh B, Finfer S, Delaney A. Balanced crystalloids compared to normal saline for fluid therapy in critically ill adult patients: Systematic review and meta-analysis protocol. medRxiv. 2021 Sep.
  • Young P, Frei D. Oxygen therapy for critically ill and post-operative patients. Journal Anesthesia. 2021 Sep.
  • Bailey R., Ramanan M, Litton E, Garrouste-Orgeas M, Tabah A, The Welcome ICU Contribtuors. Staff perceptions of family access and visitation policies in Australian and New Zealand intensive care units: The WELCOME-ICU survey. Aus Crit Care. 2021 Aug.
  • Cardona M, Dobler C, Koreshe E, Heyland D, Nguyen R, Sim J, Clark J, Psirides A. A catalogue of tools and variables from crisis and routine care to support decision-making about allocation of intensive care beds and ventilator treatment during pandemics: Scoping review. Journal Critical Care. 2021 Aug.
  • Drake M, Austin G, Dann L, Li Y, Shuker C, Psirides A. Introduction of a standardised maternity early warning system: indicative data from a before-and-after study at a large pilot site before national rollout in Aotearoa New Zealand. Anaesthesia. 2021 Aug.
  • Psirides A, Tripp D, Pegg T. Rethinking resuscitation: moving the goals. NZMJ. 2021 Aug. 134(1540)
  • Thompson K, Young P, Venkatesh B, Cohen J, Finfer S, Grattan S, Hammond N, Jan S, Li Q, Di Tanna GL, McArthur C, Myburgh J, Rajbhandari D, Taylor C. Long-term costs and cost-effectiveness of adjunctive corticosteroids for patients with septic shock in New Zealand. Australian Crit Care. 2021 Jul.
  • Josef Dankiewicz, Tobias Cronberg, Gisela Lilja, Janus C. Jakobsen, Helena Levin, Susann Ullén, Christian Rylander, Matt P. Wise, Mauro Oddo, Alain Cariou, Jan Bělohlávek, Jan Hovdenes, Manoj Saxena, Hans Kirkegaard, Paul J. Young, Paolo Pelosi, Christian Storm, Fabio S. Taccone, Michael Joannidis, Clifton Callaway, Glenn M. Eastwood, Matt P.G. Morgan, Per Nordberg, David Erlinge, Alistair D. Nichol, Michelle S. Chew, Jacob Hollenberg, Matthew Thomas, Jeremy Bewley, Katie Sweet, Anders M. Grejs, Steffen Christensen, Matthias Haenggi, Anja Levis, Andreas Lundin, Joachim Düring, Simon Schmidbauer, Thomas R. Keeble, Grigoris V. Karamasis, Claudia Schrag, Edith Faessler, Ondrej Smid, Michal Otáhal, Marco Maggiorini, Pedro D. Wendel Garcia, Paul Jaubert, Jade M. Cole, Miroslav Solar, Ola Borgquist, Christoph Leithner, Samia Abed-Maillard, Leanlove Navarra, Martin Annborn, Johan Undén, Iole Brunetti, Akil Awad, Peter McGuigan, Roy Bjørkholt Olsen, Tiziano Cassina, Philippe Vignon, Halvor Langeland, Theis Lange, Hans Friberg, Niklas Nielsen, for the TTM2 Trial Investigators. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. NEJM 2021; 384:2283-2294
  • Cohen J, Delaney A, Anstey J, Anstey M, Barge D, Bellomo R, Bhardwa V, Brinkerhoff G, Board J, Campain A, Cooper DJ, Di Tanna GL, Finnis M, Fitzgerald E, Flower O, Healey P, Hunt A, Lawrence C, Merthens J, Newby L, Pearson D, Raith E, Robertson Y, Schweikert S, Starr T, Tallott M, van der Poll A, Young P, Udy A. Dysnatremia and 6-Month Functional Outcomes in Critically Ill Patients With Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study. Crit Care Explor. 2021 Jun 8;3(6)
  • Darrell J, Bellomo R, Paul E, Bailey M, Young P, Reid A, Rockwood K, Pilcher D. Routine frailty screening in critical illness- a population-based cohort study in Australia and New Zealand. Chest 2021; Jun 2
  • The SuDDICU Investigators. Protocol summary and statistical analysis plan for the Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU) crossover, cluster randomised controlled trial. Crit Care Resusc 2021; 23(2):183-193
  • Lewis K, Almubarak Y, Møller M, Jaeschke R, Perri D, Du Y, Nishida O, Ntoumenopoulos G, Saxena M, Truwit J, Young P, Alshamsi F, Arabi Y, Rochwerg B, Karachi T, Szczeklik W, Alshahrani M, Machado F, Annane D, Antonelli M, Girard T, Cook D, Nanchal B, Piraino T, Guyatt G, Alhazzani W. The Cuff Leak Test in Critically Ill Patients: An International Survey of Intensivists. Anaesthesiol Scan 2021 May.
  • Wetterslev M, Møller M, Granholm A, Haase N, Hassager C, Lange T, Hästbacka J, Willman E, Myntar S, Shen J, An Y, Siegemund M, Young P, Aslam T, Szczeklik W, Aneman A, Arabi Y, Cronhjort M, Keus F, Perner A. New-onset atrial fibrillation in the intensive care unit: Protocol for an international inception cohort study (AFIB-ICU). Acta Anaesthesiol Scan 2021 Apr.
  • Young P. Editorial: Effect of Oxygen Therapy on Mortality in the ICU. NEJM 2021; 384:1361-1363
  • Young P, Gladwin B, Capdevila M. Is less really more for oxygen therapy in patients with acute respiratory failure? Anaesthesia Crit Care Pain Med 2021
  • Young P. Editorial: Turning up the heat on fever research? Crit Care Resusc 2021; 23(1): 4-5
  • Billot L, Bellomo R, Gallagher M, Gantas D, Hammond N, Mackle D, Micallef S, Myburgh J, Navarra L, Saxena M, Taylor C, Young P, Finfer S. The Plasma-Lyte 148 versus Saline (PLUS) statistical analysis plan: a multicentre, randomised controlled trial of the effect of intensive care fluid therapy on mortality. Crit Care Resusc 2021; 23(1): 24-31
  • Gibbons K, Schlapbach L, Horton S, Long D, Beca J, Erickson S, Festa M, d'Udekem Y, Alphonso N, Winlaw D, Johnson K, Delzoppo C, van Loon K, Gannon B, Fooken J, Blumentahl A, Young P, Butt W, Schibler A. Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Crit Care Resusc 2021; 23(1): 47-58
  • The REMAP-CAP Investigators. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. NEJM 2021 Feb.
  • Grayson K, Bailey M, Balachandran M, Banneheke P, Belletti A, Bellomo R, Naorungroj T, Serpa-Neto A, Wright J, Yanase F, Young P, Shehabi Y. The Effect of Early Sedation with Dexemedetomidine on Body Temperature in Critically Ill Patients. Crit Care Med 2021 Feb.
  • Parke R, Gilder E, Gilham M, Walker L, Bailey M, McGuinness S. A Multicenter, Open-Label, Randomized Controlled Trial of a Conservative Fluid Management Strategy Compared With Usual Care in Participants After Cardiac Surgery: The Fluids After Bypass Study. Crit Care Med 2021 Jan.
  • Mistry R, Frei D, Badenhorst C, Broadbent J. A survey of self-reported use of cricoid pressure amongst Australian and New Zealand anaesthetists: Attitudes and practice. Anaesthesia & Intensive Care 2021 Jan.
  • Litton E, Atkinson H, Anstey J, Anstey M, Campbell L, Forbes A, Hahn R, Hooper K, Kasza J, Knapp S, McGain F, Ngyuen N, Pilcher D, Reddi B, Reid C, Robinson S, Thompson K, Webb S, Young P. Optimising a targeted test reduction intervention for patients admitted to the intensive care unit: The Targeted Intensive Care Test Ordering Cluster Trial intervention. Australian Critical Care 2021 Jan.
2020 (40)
Young P, Gladwin B, Psirides A, Reid A. Unplanned admissions to the Wellington Hospital intensive care unit before, during and after New Zealand’s COVID-19 lockdown. NZMJ 2020 Dec. 133(1527); 95-103.
PROMOTE-SAH Investigators. Six-month mortality and functional outcomes in aneurysmal sub-arachnoid haemorrhage patients admitted to intensive care units in Australia and New Zealand: A prospective cohort study. J Clinical Neurosci 2020 Oct. 80:92-99
Chapple L, Summers M, Bellomo R, Chapman M, Davies A, Ferrie S, Finnis M, Hurford S, Lange K, Little L, O'Connor S, Peake S, Ridley E, Young P, Williams P, Deane A. Use of a High Protein Enteral Nutrition Formula to Increase Protein Delivery to Critically Ill Patients: A Randomized, Blinded, Parallel‐group, Feasibility Trial. Jour Parenteral & Enteral Nutrition 2020 Dec.
Darvall J, Bellomo R, Young P, Rockwood K, Pilcher D. Frailty and mortality in patients with COVID-19. Lancet 2020 Nov;5(11):E580
Frei D, Young P. Where to from here with recommendations for perioperative oxygen therapy? Anaesthesia Crit Care & Pain Med 2020 Oct.
Alhazzani W, Belley-Cote E, Moller M, Angus D, Papazian L, Arabi Y, Citerio G, Connolly B, Denehy L, Fox-Robichaud A, Hough C, Laake J, Machado F, Ostermann M, Piraino T, Sharif S, Szczeklik W, Young P, Gouskos A, Kiedrowski K, Burns K. Neuromuscular blockade in patients with ARDS: a rapid practice guideline. Intensive Care Medicine 2020 Oct.
Young P, Nickson C, Perner A. Evaluating Non-Statistically Significant Results From Trials in Practice - Reply. JAMA 2020;324(16):1680
Young P, Bailey M, Bellomo R, Bernard S, Bray J, Jakkula P, Kuisma M, Mackle D, Martin D, Nolan J, Panwar R, Reinikainen M, Skrivares M, Thomas M. Conservative or liberal oxygen therapy in adults after cardiac arrest: An individual-level patient data meta-analysis of randomised controlled trials. Resuscitation 2020 Oct.
Jakobsen J, Dankiewicz J, Lange T, Cronberg T, Lilja G, Levin H, Belohlavek J, Callaway C, Cariou A, Erlinge D, Hovdenes J, Joannidis M, Nordberg P, Oddo M, Pelosi P, Kirkegaard H, Eastwood G, Rylander C, Saxena M, Storm C, Taccone F, Wise M, Morgan M, Young P, Nichol A, Friberg H, Ullen S, Nielsen N. Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan. Trials 2020 Oct 7;21(1):831
Cardona M, Anstey M, Lewis E, Shanmugam S, Hillman K, Psirides A. Appropriateness of intensive care treatments near the end of life during the COVID-19 pandemic. Breathe 2020;16:200062
Reid A, Young P. What Intensivists Can Learn From Geriatric Medicine. ICU Management & Practice 2020;20(3)
Sutton-Smith L. A quality improvement project to improve the identification and management of delirium. Nurs Crit Care. 2020;1-7
REMAP-CAP Writing Committee. Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVI-19. The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. JAMA 2020 Sep.
Darvall J, Bellomo R, Bailey M, Paul E, Young P, Rockwood K, Pilcher D. Frailty and outcomes from pneumonia in critical illness: a population-based cohort study. BJA 2020.
Heaney J, Paul E, Pilcher D, Lin C, Udy A, Young P. Outcomes of patients with subarachnoid haemorrhage admitted to Australian and New Zealand intensive care units following a cardiac arrest. Crit Care Resusc 2020;22(3):237-244
Young P. Editorial: Hydrocortisone in septic shock: is it worth it? Crit Care Resusc 2020;22(3):189-190
Keijzers G, Macdonald S, Ude A, Arendts G, Bailey M, Bellomo R, Blecher G, Burcham J, Coggins A, Delaney A, Fatovich D, Fraser J, Harley A, Jones P, Kinnear F, May K, Peake S, Taylor D, Williams P and the ARISE FLUIDS Observational Study Group. The Australasian Resuscitation In Sepsis Evaluation: Fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand. EMA 2020. 32,586-598.
Young P, Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, Eastwood G, Finfer S, Freebairn R, King V, Linke N, Litton E, McArthur C, McGuinness S, Panwar R. Conservative oxygen therapy for mechanically ventilated adults
with suspected hypoxic ischaemic encephalopathy. Intensive Care Med. August 2020.
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Carr A, Spencer E, Mackle D, Hunt A, Judd H, Mehrtens J, Parker K, Stockwell Z, Gale C, Beaumont M, Kaur S, Bihari S, Young P. The effect of conservative oxygen therapy on systemic biomarkers of oxidative stress in critically ill patients. Free Rad Bio Med. August 2020.
The STARRT-AKI Investigators. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. NEJM 2020;383:240-251
Young P, Mackle D, Bellomo R. Correspondence: Oxygen Therapy in the ICU. NEJM 2020; 382:2577-2579
  • Young P. Stress Ulcer Prophylaxis for ICU Patients - Reply. JAMA. 2020;324(1):102-103
  • Reid A, Chapman M, Peake S, Bellomo R, Davies A, Deane A, Horowitz M, Hurford S, Lange K, Little L, Mackle D, O'Connor S, Presneill J, Ridley E, Williams P, Young P. Energy-dense vs routine enteral nutrition in New Zealand Europeans, Māori & Pacific People who are critically ill. NZMJ. 2020 June. 133(1516)
  • Deane A, Bellomo R, Chapman M, Lange K, Peake S, Young P, Iwashyna T. Reply to: Too many calories for all?. American Journal Resp & Crit Care Med. 2020 June.
  • Martin R, Sturt J, Griffiths F. The impact of digital communication on adolescent to adult mental health service transitions. Journalisms Research Nursing. 2020 May.
  • Fumitaka Y, Fujii T, Naorungroj T, Belletti A, Luethi N, Carr A, Young P, Rinaldo B. Harm of IV High-Dose Vitamin C Therapy in Adult Patients - A Scoping Review. Crit Care Med. 2020 May.
  • Poole A, Finnis M, Anstey J, Bellomo R, Bihari S, Biradar V, Doherty S, Eastwood G, Finfer S, French C, Ghosh A, Heller S, Horowitz M, Kar P, Kruger P, Maiden M, Martensson J, McArthur C, McGuinness S, Secombe P, Tobin A, Udy A, Young P, Deane A. Study Protocol and Statistical Analysis Plan for the Liberal Glucose Control in Critically Ill Patients With Pre-existing Type 2 Diabetes (LUCID) Trial. Crit Care Resusc. 2020 Jun;22(2):133-141
  • Young P, Bagshaw S, Forbes A, Nichol A, Wright S, Bellomo R, van Haren F, Litton E, Webb S. Opportunities and Challenges of Clustering, Crossing Over, and Using Registry Data in the PEPTIC Trial. Crit Care Resusc. 2020 Jun;22(2):105-109
  • Young P, Nickson C, Perner A. When Should Clinicians Act on Non-Statistically Significant Results From Clinical Trials? JAMA. May 2020.
  • Angus D, Berry S, Lewis R, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng A, Chiche J-D, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins A, Hullegie S, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill G, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb S. The Randomized Embedded Multifactorial Adaptive Platform for Comunity-acquired Pneumonia (REMAP-CAP) Study: Rationale and Design. Annals Am Thor Soc. Apr 2020.
  • Lilja G, Nielsen N, Ullén S, Nordstrom E, Dankiewicz J, Friberg H, Heimburg K, Jakobsen J, Levin H, Callaway C, Cariou A, Eastwood G, Helbok R, Hovdenes J, Kirkegaard H, Leithner C, Morgan M, Nordberg P, Oddo M, Pelosi P, Rylander C, Saxena M, Taccone F, Siranec M, Wise M, Young P, Cronberg T. Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2). Resuscitation. Mar 2020.
  • Berenyi F, Steinfort D, Ali Abdelhamid Y, Bailey M, Pilcher D, Bellomo R, Finnis M, Young P, Deane A. Characteristic and Outcomes of Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Australia and New Zealand. Ann Am Thorac Soc. Mar 2020
  • Young P, Bagshaw S, Bellomo R, Nichol D, Wright E. The Implications of the PEPTIC Trial for Clinical Practice. Crit Care Resusc. 22(1),4-5 Mar 2020
  • Wilson A, Magee F, Bailey M, Pilcher D, French C, Nichol A, Udy A, Hodgson C, Cooper J, Reade M, Young P, Bellomo R. Characteristics and Outcomes of Critically Ill Trauma Patients in Australia and New Zealand. Crit Care Med. Feb 2020
  • Harhay M, Young P, Shankar-Hari M. Could stress ulcer prophylaxis increase in mortality in high-acuity patients? Intensive Care Med 2020
  • Bellomo R, Wunderink R, Szerlip H, English S, Busse L, Deane A, Khanna A, McCurdy M, Ostermann M, Young P, Handisides D, Chawla L, Tidmarsh G, Albertson T. Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock. Crit Care 24;43. Feb 2020
  • Kim M, Moore J. Chest trauma: current recommendations for rib fractures, pneumothorax, and other injuries. Current Anesthesiology Reports. Jan 2020
  • Fujii T, Luethi N, Young P, Frei D, Eastwood G, French C, Deane A, Shehabi Y, Hajjar L, Oliveira G, Udy A, Orford N, Edney S, Hunt A, Judd H, Bitker L, Cioccari L, Naorungroj T, Yanase F, Bates S, McGain F, Hudson E, Al-Bassam W, Dwivedi D, Peppin C, McCracken P, Orosz J, Bailey M, Bellomo R. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock The VITAMINS Randomized Clinical Trial. JAMA. Jan 2020
  • The PEPTIC Investigators for ANZICS CTG, Alberta Health Services CCSCN & Irish CCTG. Young P, Bagshaw S, Forbes A, Nichol A, Wright S, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood G, Gattas D, van Haren F, Litton E, Mackle D, McArthur C, McGuinness S, Mouncey P, Navarra L, Opgenorth D, Pilcher D, Saxena M, Webb S, Wiley D, Rowan K. Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation The PEPTIC Randomized Clinical Trial. JAMA. Jan 2020
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  • Deane A, Little L, Bellomo R, Chapman M, Davies A, Ferrie S, Horowitz M, Hurford S, Lange K, Litton E, Mackle D, O'Connor S, Parker J, Peake S, Presneill J, Ridley E, Singh V, van Haren F, Williams P, Young P, Iwashyna T. Outcomes six-months after 100% or 70% of enteral calorie requirements during critical illness (TARGET): a randomized controlled trial. AJRCCM. Jan 2020
2019 (30)
  • Hammond N, Bellomo R, Gallagher M, Gattas D, Glass P, Mackle D, Micallef S, Myburgh J, Saxena M, Taylor C, Young P, Finfer S. The Plasma-Lyte 148 Versus Saline (PLUS) Study Protocol Amendment. Crit Care Resusc. 21(4),284-86. Dec 2019
  • Young P, Bagshaw S, Bailey M, Bellomo R, Mackle D, Pilcher D, Landoni G, Nichol A, Martin D. O2, do we know what to do? Crit Care Resusc. 21(4),230-32. Dec 2019
  • Young P, Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, Eastwood G, Finfer S, Freebairn R, King V, Linke N, Litton E, McArthur C, McGuinness S, Panwar R. Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX). Intensive Care Medicine 2019
  • The STARRT-AKI Investigators. STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury: Study Protocol for a Multi-National, Multi-Center, Randomized Controlled Trial. Can J Kidney Health Dis. 2019;6
  • Fujii T, Belletti A, Carr A, Furukawa T, Luethi N, Putzu A, Sartini C, Salanti G, Tsujimoto Y, Udy A, Young P, Bellomo R. Vitamin C therapy for patients with sepsis or septic shock: a protocol for a systematic review and a network meta-analysis. BMJ Open 2019;9:e033458
  • The ICU-ROX Investigators & ANZICS CTG. Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, Eastwood G, Finfer S, Freebairn R, King V, Linke N, Litton E, McArthur C, McGuinness S, Panwar R, Young P. Conservative Oxygen Therapy during Mechanical Ventilation in the ICU. NEJM. 2019 Oct
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  • Young P, Bailey M, Bass F, Beasley R, Freebairn R, Hammond N, van Haren F, Harward M, Henderson S, Mackle D, McArthur C, McGuinness S, Myburgh J, Saxena M, Turner A, Webb S, Bellomo R. Randomised evaluation of active control of temperature versus ordinary temperature management (REACTOR) trial. Intensive Care Med (2019) 45:1382-1391
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  • Cardona M, Shanmugam S, Lewis E, Psirides A, Anstey M, Hillman K. A rapid review of patient and family perspectives on inappropriateness of intensive care treatments at end of life. MedRxiv 19007138. 2019 Sep.
  • Young P, Bellomo R. The Risk of Hyperoxemia in ICU Patients: Much Ado About O2. Am J Respir Crit Care Med. 2019 Sep 17.
  • Young P. Balanced Crystalloids or 0.9% Saline in Sepsis: Beyond Reasonable Doubt? Am J Respir Crit Care Med. 2019 Sep 12.
  • Hicks P, Huckson S, Fenney E, Leggett I, Pilcher D, Litton E. The financial cost of intensive care in Australia: a multi centre registry study. MJA 2019 Aug.
  • Yanase F, Bitker L, Hessels L, Osaka E, Naorungoj T, Cutuli S, Young P, Riztema J, Hill G, Hunt A, Eastwood G, Hilton A, Bellomo R. A Pilot, Double-Blind, Randomized, Controlled Trial of High Dose Intravenous Vitamin C for Vasoplegia after Cardiac Surgery. Journal Cardiothoracic & Vascular Anesthesia 2019 Aug.
  • Dankiewicz J, Cronberg T, Lilja G, Jakobsen J, Belohlavek J, Callaway C, Cariou A, Eastwood G, Erlinge D, Hovdenes J, Joannidis M, Kirkegaard H, Kuiper M, Levin H, Morgan M, Nichol A, Nordberg P, Oddo M, Pelosi P, Rylander C, Saxena M, Storm C, Taccone F, Ullen S, Wise M, Young P, Friberg H, Nielsen N. Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2). A randomized clinical trial – Rationale and design. American Heart Journal. 2019 Jun.
  • Schlapbach L, Horton S, Long D, Beca J, Erickson S, Festa M, d'Udekem Y, Alphonso N, Winlaw D, Johnson K, Delzoppo C, van Loon K, Gannon B, Fooken J, Blumenthal A, Young P, Jones M, Butt W, Schibler A. Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial. BMJ Open. 2019;9:e026664
  • Young P, Prescott H. When less is more in the active management of elevated body temperature of ICU patients. Intensive Care Med. 2019 Jun.
  • Fujii T, Udy AA, Deane AM, Luethi N, Bailey M, Eastwood GM, Frei D, French C, Orgord N, Shehabi Y, Young PJ, Bellomo R. Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan. Crit Care Resus. 2019 Jun;21(2):119-125
  • Young PJ. Is sepsis treatment heating up? Crit Care Resusc. 2019 Jun;21(2):85-86
  • Psirides A. Special Report - Stop Doing 'Everything'. Emergency Medicine News. 2019 Jun;41(6):24-25
  • Frei D, Beasley R, Campbelll D, Leslie K, Merry A, Moore M, Myles P, Ruawai-Hamilton L, Short T, Young P. Practice patterns and perceptions of Australian and New Zealand anaesthetists towards perioperative oxygen therapy. Anaesthesia Intensive Care. 2019 May
  • Young P, Delaney A, Venkatesh B. Vasopressin in septic shock: what we know and where to next. Intensive Care Med. 2019 May.
  • Rasmussen B, Frei D, Schjørring O, Meyhoff C, Young P. Perioperative Oxygenation Targets in Adults. Current Anesthesiology Reports. 2019 Apr.
  • Kindle R, Badawi O, Celi L, Sturland S. Intensive Care Unit Telemedicine in the Era of Big Data, Artificial Intelligence, and Computer Clinical Decision Support Systems. Critical Care Clinics. 2019 Apr.
  • Hessels L, Coulson T, Seevanayagam S, Young P, Pilcher D, Marion N, Bellomo R. Development and validation of a score to identify cardiac surgery patients at high risk of prolonged mechanical ventilation. Journal Cardiothoracic Vascular Anesthesia. 2019 Mar.
  • Warrillow S, Bailey M, Pilcher D, Kazemi A, McArthur C, Young P, Bellomo R. Characteristics and Outcomes of Patients with Acute Liver Failure Admitted to Australian and New Zealand Intensive Care Units. Intern Med J. 2018 Nov.
  • Pappacena S, Bailey M, Cabrini L, Landoni G, Udy A, Pilcher DV, Young P, Bellomo R. Early dysglycemia and mortality in traumatic brain injury and subarachnoid hemorrhage. Minerva Anestesiol. 2019 Feb.
  • Young P, Bellomo R, Bernard G, Niven D, Schortgen F, Saxena M, Beasley R, Weatherall M. Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials. Intensive Care Medicine 2019.
  • Beasley R, Mackle D, Young P. Oxygen - a new look at an old therapy. Journal Royal Society New Zealand 2019.
  • Weinkove R, Bowden E, Wood C, Campion V, Carter J, Hall R, Weatherall M, Beasley M, Young P. A randomized controlled feasibility trial of paracetamol during febrile neutropenia in hemato-oncology patients. Leukemia & Lymphoma 2019
  • Lewis E, Harrison R, Hanly L, Psirides A, Zammit A, McFarland K, Dawson A, Hillman K, Barr M, Cardona M. End-of-life priorities of older adults with terminal illness and caregivers: A qualitative consultation. Health Expect. 2019 Jan;22(3)
2018 (23)
  • Young PJ. P-values have no value, but there is a better (Bayesian) way. Emergency Med News. 2018 Dec;40(12):18-19
  • Young PJ, Bellomo R, Chapman MJ, Deane AM, Peake SL. What should we target after TARGET? Crit Care Resuscitations. 2018 Dec;20(4):252-253
  • Magee F, Wilson A, Bailey M, Pilcher D, Secombe P, Young P, Bellomo R. Trauma-related admissions to intensive care units in Australia: the influence of indigenous status on outcomes. MJA 2018 Dec
  • Vincent JL, Nielsen ND, Shapiro NI, Gerbasi ME, Grossman A, Doroff R, Zeng F, Young PJ, Russell JA. Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database. Ann Intensive Care 2018 Nov;8(1):107
  • Landoni G, Pieri M, Young PJ, Bellomo R. Why don't multicenter randomized controlled trials (RCT) confirm the positive findings of single center RCTs in acute care? (Zeno's Paradox of the Tortoise and Achilles revisited). Minerva Anestesiol 2018 Oct 30
  • The TARGET Investigators, for the ANZICS Clinical Trials Group. Energy-Dense versus Routine Enteral Nutrition in the Critically Ill. NEJM 2018 Oct. 379:1823-1834
  • Frei DR, Young PJ. Oxygen therapy in acute resuscitation. Curr Opin Crit Care 2018 Dec;24(6):506-511
  • Young P, ICU_ROX Investigators. Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase. Crit Care Resusc 2018 Sep;20(3):246-247
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  • Carr A, Wohlrab C, Young P, Bellomo R. Stability of intravenous vitamin C solutions: a technical report. Crit Care Resusc. 2018 Sep;20(3):180-181
  • Cutuli S, Osawa E, Glassford N, Marshall D, Eyeington C, Eastwood G, Young P, Bellomo R. Body temperature measurement methods and targets in Australian and New Zealand intensive care units. Crit Care Resusc. 2018 Sep;20(3):241-244
  • Young P, Bagshaw S, Forbes A, Nichol A, Wright S, Bellomo R, Bailey M, Beasley R, Eastwood G, Festa M, Gattas D, van Haren F, Litton E, Mouncey P, Navarra L, Pilcher D, Mackle D, McArthur C, McGuinness S, Saxena M, Webb S, Rowan K. A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol. Crit Care Resusc 2018 Sep;20(3):182-189
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  • Mazer C, Whitlock R, Fergusson D, Belley-Cote E, Connolly K, Khanykin B, Gregory A, de Medicis E, Carrier F, McGuinness S, Young P, Byrne K, Villar J, Royse A, Grocott H, Seeberger M, Mehta C, Lellouche F, Hare G, Painter T, Fremes S, Syed S, Bagshaw S, Hwang N, Rose C, Hall J, Dai D, Mistry N, Thorpe K, Verma S, Juni P, Shehata N. Six-month outcomes after restrictive or liberal transfusion for cardiac surgery. NEJM. 2018 Aug
  • Salter R, Bailey M, Bellomo R, Eastwood G, Goodwin A, Nielsen N, Pilcher D, Nichol A, Saxena M, Shehabi Y, Young P. Changes in temperature management of cardiac arrest patients following publication of the target temperature management trial. Crit Care Med. 2018 Jul.
  • Dallimore J, Ebmeier S, Thayabaran D, Bellomo R, Schortgen F, Saxena M, Beasley R, Weatherall M, Young P. Effect of active temperature management on mortality in intensive care unit patients. Crit Care Resusc. 2018 Jun;20(2):150-163
  • Ebmeier S, Barker M, Bacon M, Beasley R, Bellomo R, Knee Chong C, Eastwood G, Gilchrist J, Kagaya H, Pilcher J, Reddy S, Ridgeon E, Sarma N, Spragas S, Tanaka A, Tweedie M, Weatherall M, Young P. A two centre observational study of simultaneous pulse oximetry and arterial oxygen saturation recordings in intensive care unit patients. Anaesth Intensive Care 2018 May;46(3)
  • Chu D, Kim L, Young P, Zamiri N, Almenawer S, Jaeschke R, Szczeklik W, Schunemann H, Neary J, Alhazzani W. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet 2018 Apr;391(10131):1693-1705
  • Jarden R, Sutton-Smith L, Boulton C. Oral intak evolution in patient following critical illness: an ICU cohort study. Nurs Crit Care 2018 Apr 16
  • Dallimore J, Bhatnagar R. Bleeding or clotting: an intracranial dilemma. BMJ Case Rep 2018
  • Sullivan T, Moore J, Klein A, Jenkins D, Williams L, Roscoe A, Tsang W. Evaluation of the Clinical Utility of Transesophageal Echocardiography and Invasive Monitoring to Assess Right Ventricular Function During and After Pulmonary Endarterectomy. Cardiothoracic Vascular Anesthesia 2018 Apr;32(2):771-778
  • TARGET investigators on behalf of the ANZICS CTG. Statistical analysis plan for The Augmented versus Routine Approach to Giving Energy Trial (TARGET). Crit Care Resusc. 2018 Mar;20(1):15-21
  • TARGET investigators on behalf of the ANZICS CTG. Study protocol for The Augmented versus Routine Approach to Giving Energy Trial (TARGET). Crit Care Resusc. 2018 Mar;20(1):6-14
  • Mackle DM, Bailey MJ, Beasley RW, Bennett VL, Deane AM, Eastwood GM, Finfer S, Freebairn RC, Litton E, Linke NJ, McArthur CJ, McGuinness SP, Panwar R, Young PJ. Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX). Crit Care Resusc 2018 Mar;20(1):22-32
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  • Al-bassam W, Kubicki M, Bailey M, Walker L, Young P, Pilcher D, Bellomo R. Characteristics, incidence, and outcome of patients admitted to the intensive care unit with myasthenia gravis. Journal Critical Care. 2018 Jun;45:90-94
2017 (16)
  • Young PJ, Mackle DM, Bailey MJ, Beasley RW, Bennett VL, Deane AM, Eastwood GM, Finfer S, Freebairn RC, Litton E, Linke NJ, McArthur CJ, McGuinness SP, Panwar R, Bellomo R. Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase. Crit Care Resusc 2017 Dec;19(4):344-354
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  • Young P. Learning Healthcare Systems Will Protect Patients From Unscientific Practice Variation. Ann Am Thorac Soc 2017 Nov 28.
  • Mazer C, Whitlock R, Fergusson D, Hall J, Belley‑Cote E, Connolly K, Khanykin B, Gregory A, de Medicis E, McGuinness S, Rose A, Carrier F, Young P, Villar J, Grocott H, Seeberger M, Fremes S, Lellouche F, Syed S, Byrne K, Bagshaw S, Hwang N, Mehta C, Painter T, Royse C, Verma S, Hare G, Cohen A, Thorpe K, Juni P, Shehata N. Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery. NEJM 2017;377:2133-2144
  • Young P, Nielsen N, Saxena M. Fever control. Intensive Care Med 2017 Oct.
  • McClean K, Mullany D, Huckson S, van Lint A, Chavan S, Hicks P, Hart G, Paul E, Pilcher D. Identification and assessment of potentially high-mortality intensive care units using the ANZICS Centre for Outcome and Resource Evaluation clinical registry. Crit Care Resusc 2017 Sep;19(3):230-238

  • Hammond NE, Bellomo R, Gallagher M, Gattas D, Glass P, Mackle D, Micallef S, Myburgh J, Saxena M, Taylor C, Young P, Finfer S. The Plasma-Lyte 148 v Saline (PLUS) study protocol: a multicentre, randomised controlled trial of the effect of intensive care fluid therapy on mortality. Crit Care Resusc 2017 Sep;19(3):239-246

  • Myers JA, Powell DMC, Aldington S, Sim D, Psirides A, Hathaway K, Haney MF. The impact of fatigue on the non-technical skills performance of critical care air ambulance clinicians. Acta Anaesthesia Scand 2017 Sep 13
  • Deane AM, Hodgson CL, Young P, Little L, Singh V, Poole A, Young M, Mackle D, Lange K, Williams P, Peake SL, Chapman MJ, Iwashyna TJ. The rapid and accurate categorisation of critically ill patients (RACE) to identify outcomes of interest for longitudinal studies: a feasibility study. Anaesth Intensive Care 2017 Jul;45(4):476-484
  • Smith G, Prytherch D, Psirides AJ. Chapter 15: An Overview of the Afferent Limb. Textbook of Rapid Response Systems: concept & implementation 2nd ed. Springer 2017 Jul
  • Jones D, Holmes J, Currey J, Fugaccia E, Psirides AJ, Singh MY, Fennessy GJ, Hillman K, Pilcher DV, Bellomo R, DeVita M. Proceedings of the 12th International Conference on Rapid Response Systems and Medical Emergency Teams. Anaesth Intensive Care 2017 Jul;45(4):511-517
  • Ridgeon E, Bellomo R, Aberegg S, Mac Sweeney R, Varughese R, Landoni G, Young P. Effect sizes in ongoing randomised controlled critical care trials. Critical Care 2017 June; 21:32
  • Khanna A, English S, Wang X, Ham K, Tumlin J, Szerlip H, Busse L, Altaweel L, Albertson T, Mackey C, McCurdy M, Boldt D, Chock S, Young P, Krell K, Wunderink R, Ostermann M, Murugan R, Gong M, Panwar R, Hastabacka J, Favory R, Venkatesh B, Thompson T, Bellomo R, Jensen J, Kroll S, Chawla L, Tidmarsh G, Deane A. Angiotensin II for the Treatment of Vasodilatory Shock. New England Journal of Medicine. 2017 May
  • Perner A, Browne J, Joannidis M, Young P, Hjortup P, Pettilä V. Fluid management in acute kidney injury. Intensive Care Medicine. 2017 May
  • Reddy S, Bailey M, Beasley R, Bellomo R, Mackle D, Psirides A, Young P. Effect of 0.9% Saline or Plasma-Lyte 148 as Crystalloid Fluid Therapy in the Intensive Care Unit on Blood Product Use and Postoperative Bleeding after Cardiac Surgery. Journal of Cardiothoracic and Vascular Anesthesia. 2017 Apr
  • Ritzema J, Young P. Editorial - Admitting elderly patients to ICU, Is it just about survival. New Zealand Medical Journal. 2017 Apr;130(1453):8-10
  • Young P, Bailey M, Beasley R, Beasley RW, Freebairn RC, Hammond NE, Haren FM, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner A, Webb SA, Bellomo R. Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial. Crit Care Resusc. 2017 Mar;19(1):81-87
REACTOR study
2016 (29)
  • Sutton L, Jarden R. Improving the quality of nurse-influenced patient care in the intensive care unit. Nursing in Critical Care 2016 Dec
  • Joint College of Intensive Care Medicine and Australian and New Zealand Intensive Care Society Special Interest Group on Rapid Response Systems. Resource use, governance and case load of rapid response teams in Australia and New Zealand in 2014. Crit Care Resusc 2016 Dec;18(4):275-282
  • Chalwin R, Radford S, Psirides A, Laver R, Bierer P, Rai S, Knott C, Dyett J, Jones D. Participant perceptions of a rapid response team training course. Crit Care Resusc 2016 Dec;18(4):283-288
  • Coombs M, Mitchell M, James S, Wetzig K. Intensive care bereavement practices across New Zealand and Australian intensive care units: a qualitative content analysis. Journal of Clinical Nursing 2016 Nov.
  • Young P, Bellomo R, Landoni G. Letter: timing of initiation of renal replacement therapy in critically ill patients with acute kidney injury. JAMA 2016;316(11):1213-1214
  • Bellomo R, Landoni G, Young P. Improved survival in critically ill patients: are large RCTs more useful than personalised medicine? Yes. Intensive Care Med 2016 Sep
  • Reddy S, Bailey M, Beasley R, Bellomo R, Mackle D, Psirides A, Young P. Effect of saline 0.9% or Plasma-Lyte 148 therapy on feeding intolerance in patients receiving nasogastric enteral nutrition. Crit Care Resusc 2016 Sep;18(3):198-204
  • Young P, Machado F, Finfer S. What's new on balanced crystalloid solutions? Intensive Care Med 2016 August
  • Casemento A, Bellomo R, Young P. Reply to Letter: Could one degree in temperature change the world? Maybe for targeted temperature management! Resuscitation 2016 August
  • Casemento A, Minson A, Radford S, Martensson J, Ridgeon E, Young P, Bellomo R. A comparison of therapeutic hypothermia and strict therapeutic normothermia after cardiac arrest. Resuscitation 2016 June;106:83-88
  • Young P. Acetaminophen to treat fever in intensive care unit patients with likely infections: a response from the author of the HEAT trial. Journal Thoracic Diseases 2016
  • Psirides A, Hill J, Jones D. Rapid Response Team activation in New Zealand hospitals - a multicentre prospective observational study. Anaesth Intensive Care 2016;44(3):391-397
  • Young P. Saline Is the Solution for Crystalloid Resuscitation. Crit Care Med 2016 May
  • Young P, Bailey M, Bellomo R. Aute Kidney Injury with Buffered Crystalloid vs Saline Among ICU Patients - Reply. JAMA 2016;315(14):1521
  • Hales C, de Vries, K, Coombs M. Managing social awkwardness when caring for morbidly obese patients in intensive care: a focused ethnography. Int Journ Nursing Studies. 2016 June; 58:82-89
  • Young P, Saxena M, Beasley R. Correspondence: Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. NEJM 2016 March 31;374:1291-1293
  • Tipping C, Bailey M, Bellomo R, Berney S, Buhr H, Denehy L, Harold M, Holland A, Higgins A, Iwashyna T, Needham D, Presneill J, Saxena M, Skinner E, Webb S, Young P, Zanni J, Hodgson C. The ICU mobility scale has construct and predictive validity and is responsive - a multicenter observational study. Annals of the American Thoracic Society. 2016 Mar
  • Coombs M, Nelson K, Psirides A, Suter N, Pedersen A. Characteristics and dying trajectories of adult hospital patients from acute care wards who die following review by the rapid response team. Anaesth Intensive Care. April 2016. 44(2):262-269
  • Coombs M, Tang J, Long-Sutehall T. Vigilant attentiveness in families observing deterioration in the dying intensive care patient: a secondary analysis study. Intensive and Critical Care Nursing. April 2016.33:65-71
  • Reddy S, McGuinness S, Parke R, Young P. Choice of fluid therapy and bleeding risk after cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia.
  • Reddy S, Weinberg L, Young P. Review: Crystalloid fluid therapy. Critical Care 2016. 20:59
  • Hodgson C, Bailey M, Bellomo R, Berney S, Buhr H, Denehy L, Gabbe B, Harold M, Higgins A, Iwashyna T, Papworth R, Parke R, Batman S, Presneill J, Saxena M, Skinner E, Tipping C, Young P, Webb S. Trial of Early Activity and Mobilisation Study Investigators. Crit Care Med. 2016 Mar 10
  • Reade M, Eastwood G, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuiness S, Mulder J, O’Donoghue S, Simpson N, Young P. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium. JAMA. 2016 Mar 15
  • Ridgeon E, Young P, Bellomo R, Mucchetti M, Limbo R, Landoni G. The Fragility Index in Multicenter Randomized Controlled Critical Care Trials. Crit Care Med. July 2016;44(7):1278-1284
  • Ridgeon E, Bellomo R, Myburgh J, Saxena M, Weatherill M, Jahan R, Arawwawala D, Bell S, Butt W, Camsookai J, Carle C, Cheng A, Cirstea E, Cohen J, Crenshaw J, Delaney A, Eastwood G, Eliott S, Franke U, Gartner D, Green C, Howard-Griffin R, Inskip D, Litton E, MacIsaac C, McCairna A, Mahambrey T, Moondi P, Newby L, O’Connor S, Pegg C, Pope A, Reschreieter H, Richards B, Robertson M, Rodgers H, Shehabi Y, Smith I, Smith J, Smith N, Tilsley A, Whitehead C, Willett E, Wong K, Woodford C, Wright S, Young P. Validation of a classification system for causes of death in critical care: an assessment of inter-rater reliability. Crit Care Resusc. Mar 2016;18(1):50-54
  • Myers J, Powell D, Psirides A, Hathaway K, Aldington S, Haney M. Non-technical skills in the critical care air ambulance environment: introduction of an adapted rating instrument - an observational study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. Mar 2016;24(24)
  • Kallesen M, Psirides A, Huckabee M-L. Comparison of Cough Reflex Testing with Videoendoscopy in Recently Extubated ICU Patients. Journal Crit Care. Feb 2016.
  • Sutton L, Jutel A. Alcohol withdrawal syndrome in critically ill patients: identification, assessment and management. Crit Care Nurse. Feb 2016;36(1):28-38
  • Rosemergy I, Psirides A, Adler J. Cannabidiol oil in the treatment of super refractory status epilepticus. A case report. Seizure 35 (2016) 56-58
2015 (19)
  • Mullins C, Psirides A. Activities of a Medical Emergency Team - a prospective observational study of 795 calls. Anaesthesia and Intensive Care 2016;44(1):34-43
  • Kumar A, Psirides A, Maheshwari N, Chawla V, Mandal A. Framework for decision-making and management of end-of-life decisions in Intensive Care Units: A modified protocol. Indian Journal of Critical Care Medicine 2015 Nov. 19(11):655-660
  • Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellow R. Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit. The SPLIT Randomised Clinical Trial. JAMA. 2015;314(16):1701-1710
SPLIT trial
  • Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, van Haren F, Holliday M, Henderson S, Mackle D, McArthur C, McGuinness S, Myburgh J, Weatherill M, Webb S, Beasley R. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. The HEAT Trial. NEJM. 2015; 373:2215-2224
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  • Peake S, Young P, Chapman M. Correspondence: ‘Permissive Underfeeding or Standard Enteral Feeding in Critical Illness’. NEJM. 2015 Sep; 373:1173-1176
  • Panwar R, Hardie M, Bellomo R, Barrot L, Eastwood GM,6, Young PJ, Capellier G, Harrigan PW, Bailey M. Conservative Versus Liberal Oxygenation Targets for Mechanically Ventilated Patients - a Pilot Multicenter Randomized Controlled Trial. Am J Respir Crit Care Med 2015 Sep 3
  • Young PJ, Beasley RW, Capellier G, Eastwood GM, Webb SA. Oxygenation targets, monitoring in the critically ill: a point prevalence study of clinical practice in Australia and New Zealand. Crit Care Resusc. 2015 Sep; 17(3):202-7
  • Walker LJC, Young P. Fluid administration, vasopressor use and patient outcomes in a group of high-risk cardiac surgical patients receiving postoperative goal-directed haemodynamic therapy: a pilot study. Anaesthesia and Intensive Care. 2015 Sep; 43 (5)
  • Saxena M, Taylor C, Hammond N, Young P, Mysore J, Bilot L, Myburgh A, Myburgh J. A multi centre audit of temperature patterns after traumatic brain injury. Crit Care Resusc. 2015 Jun; 17(2):129-34
  • Young P. The illusion of physiological gain and rise of ‘less is more’. Editorial, Intensive Care Monitor. 2015 May/June, Vol.22, Issue 3.
  • Jones D, Hicks P, Currey J, Holmes J, Fennessy GJ, Hillman K, Psirides A, Rai S, Singh MY, Pilcher DV, Bhonagiri D, Hart GK, Fugaccia E. Findings of the first ANZICS conference on the role of intensive care in Rapid Response Teams. Anaesthesia and Intensive Care. 2015 May. 43(3):369-379
  • The SUP-ICU co-authors. Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiologica Scandinavica. 2015 May. 59(5):576-585
  • The SUP-ICU co-authors. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med. 2015 April: doi:10.1007/s00134-015-3725-1
  • Kallesen M, Psirides A, Huckabee M. Recovery of Cough Following Extubation after Coronary Artery Bypass Grafting: A Prospective Study. Journal of Critical Care. 2015 Mar: doi:10.1016/j.jcrc.2015.03.013
  • Donnelly S, Psirides A. Relatives’ and staff’s experience of patients dying in ICU. Quarterly Journal of Medicine. 2015 Mar: doi:10.1093/qjmed/hcv059
  • Reddy SK, Young PJ, Beasley RW, Mackle DM, cGuinness SP, McArthur CJ, Henderson SJ, Weinberg L, French CJ, Orford NR, Bailey MJ, Bellomo R. Overview of the study protocols and statistical analysis plan for the Saline versus Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research program. Crit Care Resusc. 2015 Mar;17(1):29-36
SPLIT trial
  • The TEAM Study Investigators. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Critical Care. 2015 Feb: doi:10.1186/s13054-015-0765-4
  • Saxena M, Young P, Pilcher D, Bailey M, Harrison D, Bellomo R, Finfer S, Beasley R, Hyam J, Menon D, Rowan K, Myburgh J. Early temperature and mortality in critically ill patients with acute neurological diseases: trauma and stroke differ from infection. Intensive Care Medicine. 2015 Feb.
  • Tripp DG, Purdie G, Hicks P. Trends in the incidence of intensive care unit invasive mechanical ventilation and subsequent 2-year survival in very elderly New Zealanders. Intern Med J. 2015 Jan;45(1):80-5
2014 (17)
  • Weinkove R, Bailey M, Bellomo R, Saxena M, Tam C, Pilcher D, Beasley R, Young P. Association between early peak temperature and mortality in neutropenic sepsis. Annals of Haematology. Dec 2014: doi 10.1007/s00277-014-2273-z
  • Hodgson C, Stiller K, Needham D, Tipping C, Harold M, Baldwin C, Bradley S, Berney S, Caruana L, Elliott D, Green M, Haines K, Higgins A, Kaukonen K, Leditschke I, Nickels M, Paratz J, Patman S, Skinner E, Young P, Zanni J, Denehy L, Webb S. Expert consensus and recommendations on safety criteria for active mobilisation of mechanically ventilated critically ill adults. Critical Care 2014, 18:658
  • Reddy S, Bailey M, Beasley R, Bellomo R, Henderson S, Mackle D, McArthur C, Mehrtens J, Myburgh J, McGuinness S, Psirides A, Young P. The SPLIT study: a protocol for a multicentre cluster-randomised double crossover study of 0.9% saline vs. Plasma-Lyte 148 for intensive care fluid therapy. Crit Care Resusc 16(4):274-279
  • Young P, Joannidis M. Crystalloid fluid therapy: is the balance tipping towards balanced solutions? Intensive Care Medicine. Nov 2014. doi:10.1007/s00134-014-3531-1
  • Young P, Bailey M, Bellomo R, Bernard S, Dicker B, Freebairn R, Henderson S, Mackle D, McArthur C, McGuinness S, Smith T, Swain A, Weatherall M, Beasley R. Hyperoxic therapy or normoxic therapy after out-of-hospital cardiac arrest (HOT OR NOT): a randomised controlled feasibility trial. Resuscitation. 2014. doi:10.1016/j.resuscitation.2014.09.011
HOTorNOT
  • Eastwood GM, Litton E, Bellomo R, Bailey MJ, Festa M, Beasley RW, Young PJ. Opinions and practice of stress ulcer prophylaxis in Australian and New Zealand intensive care units. Crit Care Resusc. 2014 Sep;16(3):170-4
  • Litton E, Eastwood GM, Bellomo R, Beasley R, Bailey MJ, Forbes AB, Gattas DJ, Pilcher DV, Webb SA, McGuinness SP, Saxena MK, McArthur CJ, Young P. A multicentre feasibility study evaluating stress ulcer prophylaxis using hospital-based registry data. Crit Care Resusc. 2014 Sep;16(3):158-63
  • Panwar R, Young P, Capellier G. Conservative oxygen therapy in mechanically ventilated patients. Crit Care Med. 2014 Sep;42(9):e630-1
  • Gantner D, Farley K, Bailey M, Huckson S, Hicks P, Pilcher D. Mortality related to after-hours discharge from intensive care in Australia and New Zealand, 2005-12. Intensive Care Medicine. doi: 10.1007/s00134-014-3438-x
  • Pilcher D, Hicks P, Huckson S. Intensive Care registries in Australia and New Zealand. ICU Management 2014 13(4):44-47
  • Jarden R, Sutton L. A practice change initiative to improve the provision of enteral nutrition to intensive care patients. Nursing in Critical Care. doi: 10.1111/nicc.12107
  • Eastwood GM, Young PJ, Bellomo R. The impact of oxygen and carbon dioxide management on outcome after cardiac arrest. Curr Opin Crit Care. 2014 Apr 8.
  • Young PJ, Delaney AP, Dulhunty JM, Venkatesh B. Critical care statistical analysis plans. In reply. Crit Care Resus. 2014 Mar; 16(1) 76-7
  • Hodgson C, Berney S, Haines K, Harrold M, Young P, Buhr H, Needham D. Development of a mobility scale for use in a multicentre Australian and New Zealand trial of early activity and mobilisation in ICU. American Thoracic Society International Conference Abstracts B56. Neurocognitive and Neuromuscular Issues in the ICU, 2013, pp.A3123
  • Pedersen A, Psirides A, Coombs M. Models & activities of Critical Care Outreach in New Zealand hospitals: results of a national census. Nursing in Critical Care. 2014 Feb.
  • Young P, Saxena M. Fever management in intensive care patients with infections. Critical Care 2014, 18
  • Young P, Bellomo R. Fever in sepsis: is it cool to be hot? Critical Care. 2014 Feb; 18:109
2013 (12)
  • Young P, Ganter D, Nickson C. Can Social Media bridge the gap between research & practice? Crit Care Resus. 2013 Dec; 15(4):257-258
  • Young P, Weatherall M, Saxena M, Bellomo R, Freebainr R, Hammond N, van Haren F, Henderson S, McARthur C, McGuiness S, Mackle D, Myburgh J, Webb S, Beasley R and the ANZICS Clinical Trials Group. The statistical analysis plan for the HEAT trial: a multi-centre randomised placebo controlled trial of IV paracetamol in ICU patients with fever and infection. Crit Care Resus. 2013 Dec; 15(4):279-286
  • Hodgson C, Needham D, Haines K, Bailey M, Ward A, Harrold M, Young P, Zanni J, Buhr H, Higgins A, Presneill J, Berney S. Feasability and inter-rater reliability of the ICU Mobility Scale. Heart & Lung: The Journal of Acute and Critical Care. 2013 Nov
  • James S, Quirke S, McBride-Henry K. Staff perception of patient discharge from ICU to ward-based care. Nurs Crit Care. 2013 Nov;18(6):297-306
  • Buchanan S, Rosemergy I, Healy P. Drug-induced subacute cutaneous lupus erythematosus due to treatment with interferon beta-1a. N Z Med J. 2013 Aug 2;126(1379):98-101
  • Hammond NE, Saxena MK, Taylor C, Young P, Seppelt I, Glass P, Myburgh J. Temperature management of non-elective intensive care patients without neurological abnormalityes: a point prevalence study of practice in Australia and New Zealand. Crit Care & Resuscitation. 2013 Sep;15(3):228-33
  • Wirawan IM, Aldington S, Griffiths RF, Ellis CJ, Larsen PD. Cardiovascular investigations of airline pilots with excessive cardiovascular risk. Aviat Space Environ Med. 2013 Jun;84 (6): 608-12
  • Saxena M, Taylor C, Hammond N, Young P, Seppelt I, Glass P, Myburgh J. Temperature management in patients with acute neurological lesions: an Australian and New Zealand point prevalence study. Crit Care & Resuscitation. 2013 June;15(2):110-118
  • Fernando J, Ikeda T, Psirides A, Young P. Admission source predicts delay to antimicrobial therapy in septic shock - a retrospective cohort study. Crit Care & Shock (2013) 16:37-44
  • Schneider A, Eastwood G, Bellomo R, Bailey M, Lipcsey M, Pilcher D, Young P, Stow P, Santamaria J, Stachowski E, Suzuki S, Cz N, Pilcher J. Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation. 2013 Mar; doi:10.1016/j.resuscitation.2013.02.014
  • Young PJ, Baker S, Cavazzoni E, Erickson SJ, Krishnan A, Kruger PS, Rashid AH, Wibrow BA. A case series of critically ill patients with anti-N-methyl-D-aspartate receptor encephalitis. Crit Care & Resuscitation. 2013 Mar;15(1):8-14
  • Psirides A, Hill J, Hurford S. A review of rapid response team activation parameters in New Zealand hospitals. Resuscitation 84 (2013) 1040-1044
2012 (22)
  • Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, Haren F, Henderson S, McArthur C, McGuinness S, Mackle D, Myburgh J, Weatherall M, Webb S, Beasley R, and the ANZICS CTG. The HEAT trial: a protocol for a multicentre randomised placebo-controlled trial of IV paracetamol in ICU patients with fever and infection. Crit Care & Resuscitation. 2012 Dec; 14(4):290-296
  • Webb SA, Young P, Bellomo R. The "sweet spot" for physiological targets in critically ill patients. Crit Care & Resuscitation. 2012 Dec; 14(4):253-5
  • Tipping CJ, Young P, Romero L, Saxena M, Dulhunty J, Hodgson C. A systematic review of measurements of physical function in critically ill adults. Crit Care & Resuscitation. 2012 Dec; 14(4):302-11
  • Young P, Beasley R. The association between SpO2 values and mortality - interpret with caution. Resuscitation. 2012.09.40
  • Pilcher M, Young P, Weatherall M, Rahman I, Bonser R, Beasley R. A systematic review and meta-analysis of the cardioprotective effects of remote ischaemic preconditioning in open cardiac surgery. J R Soc Med. 2012 October; 105(10): 436-445
  • Young P, Hodgson C, Dulhunty J, Saxena M, Bailey M, Bellomo R, Davies A, Finfer S, Kruger P, Lipman J, Myburgh J, Peake S, Seppelt I, Streat S, Tate R, Webb S, and the ANZICS CTG. End points for Phase II trials in Intensive Care: Recommendations from the Australian and New Zealand Clinical Trials Group consensus panel meeting. Crit Care & Resuscitation 2012; 14; 211-215
  • Mackle D. Making ICU Research Happen: a Qualitative Descriptive Study About the Role of the Research Nurse in New Zealand Level III Intensive Care Units. Master's of Nursing, Victoria University 2012. http://hdl.handle.net/10063/2545
  • Young P, Pilcher J, Patel M, Cameron L, Braithwaite I, Weatherall M, Beasley R. Delivery of titrated oxygen via a self-inflating resuscitation bag. Resuscitation. 2010.08.330
  • Williams J, Young P, Pilcher J, Weatherall M, Miller J, Beasley R, La Flamme A. Remote ischaemic preconditioning does not alter perioperative cytokine production in high-risk cardiac surgery. Heart Asia. 2012;4:1 97-101
  • Shah N, Michel J, Ashton G, Psirides A, Mahon B, Larsen P, Sasse. Do cardiovascular risk factors predict complications in patients awaiting coronary artery bypass grafting? Heart, Lung & Circulation. August 2012; 21(8):513-514
  • Michel J, Shah N, Ashton G, Psirides A, Mahon B, Larsen P, Sasse. New Zealand cardiac clinical prioritisation system: left ventricular impairment predicts ICU length of stay after coronary artery bypass graft surgery. Heart, Lung & Circulation. August 2012; 21(8):503
  • Michel J, Shah N, Ashton G, Psirides A, Mahon B, Larsen P, Sasse. Does EuroSCORE predict preoperative complications in patients awaiting coronary artery bypass surgery: lessons from the clinical cardiac prioritisation system database. Heart, Lung & Circulation. August 2012; 21(8):503-504
  • Tripp D. Did an acute medical assessment unit improve the initial assessment and treatment of community acquired pneumonia: a retrospective audit. New Zealand Medical Journal 2012; 125 (1343) 60-67
  • Tripp D. Old Man's Friend? Resuscitation decisions in patients hospitalised with pneumonia. New Zealand Medical Journal 2012; 125 (1343) 68-74
  • Jefferies S, Saxena M, Young P. Paracetamol in critical illness: a review. Critical Care & Resuscitation 2012; 14; 74-80
  • Miles L, Bailey M, Young P, Pilcher D. Differences in mortality based on worsening ratio of partial pressure of oxygen to fraction to inspired oxygen corrected for immune system status an respiratory support. Critical Care & Resuscitation 2012; 14; 25-32
  • Poynter C, Garden A, Young PJ. Registrar sleep patterns and supervision during two different rosters in a tertiary Australasian intensive care unit. Critical Care & Resuscitation 2012; 14; 5-9
  • Young PJ, Dalley P, Garden A, Horrocks C, Mahon B, Miller J, Pilcher J, Weatherall M, WIlliams J, Young W, Beasley R. A pilot study investigating the effects of remote ischaemic preconditioning in high-risk cardiac surgery using a randomized controlled double-blind protocol. Basic Research in Cardiology 2012; 107(3):1-10
  • Young P, Beasley R, Bailey M, Bellomo R, Eastwood G, Nichol A, Pilcher D, Yunos N, Egi M, Hart G, Reade M, Cooper DJ. The association between early arterial oxygenation and mortality in ventilated patients with acute ischaemic stroke. Critical Care & Resuscitation 2012; 14; 14-19
  • Myers J, Psirides A, Hathaway K, Larsen P. Air Transport by the Wellington Flight Service: a descriptive analysis of inter-hospital transfers over a five year period in the Wellington region. New Zealand Medical Journal 2012 Mar; 125(1351)
  • Young PJ, Saxena M, Beasley R, Bellomo R, Bailey M, Pilcher D, Finfer S, Harrison D, Myburgh J, Rowan K. Early peak temperature and mortality in critically ill patients with or without infection. Intensive Care Medicine 2012 Jan 31
  • Pilcher J, Weatherall M, Shirtcliffe P, Bellomo R, Young P, Beasley R. The effect of hyperoxia following cardiac arrest - a systematic review and meta-analysis of animal trials. Resuscitation 2012 Jan 5
2011 (13)
  • Saxena MK, Hammond NE, Taylor C, Young P, Reade MC, Bellomo R, Myburgh J. A survey of fever management for febrile intensive care patients without neurological injury. Critical Care & Resuscitation 2011 Dec;13(4):238-43
  • Eastwood G, Bellomo R, Bailey M, Taori G, Pilcher D, Young P, Beasley R. Arterial oxygen tension and mortality in mechanically ventilated patients. Intensive Care Medicine 2011, online first 30/11/11. doi:10.1007/s00134-011-2419-6
  • Harper E. The development of intensive care nursing as a specialty at Wellington Hospital intensive care unit, Wellington, New Zealand, 1964-1989. Master's of Nursing thesis, Victoria University; 25-11-2011: http://hdl.handle.net/10063/1948
  • Jefferies S, Weatherall M, Young P, Eyers S, Beasley R. Systematic review and meta-analysis of the effects of antipyretic medications on mortality in Streptococcus pneumoniae infections. Postgrad Med J. doi:10.1136/postgradmedj-2011-130217
  • Saxena MK, Hammond NE, Taylor C, Young P, Reade MC, Bellomo R, Myburgh J. A survey of fever management in febrile intensive care patients without neurological injury. Critical Care 2011, 15 (Suppl 3): p18
  • Saxena M, Young P, Beasley R, Bailey M, Bellomo R, Pilcher D, Finfer S, Harrison D, Myburgh J, Rowan K. Early peak temperature and mortality in critically ill patients with and without infection. Critical Care 2011, 15 (Suppl 3): p24
  • Young P, Saxena M, Beasley R. Fever and antipyresis in infection. Medical Journal of Australia 2011; 195(8): 458-459
  • Knott C, Psirides A, Young P, Sim D. A retrospective cohort study of the effect of medical emergency teams on documentation of advance care directives. Critical Care & Resuscitation 2011;13:167-174
  • Maher L, Young P. Cardiac arrest complicating neostigmine use for bowel opening in a critically ill patient. Critical Care & Resuscitation 2011;13:192-193
  • Jefferies S, Weatherall M, Young P, Beasley R. A systematic review of the accuracy of peripheral thermometry in estimating core temperatures among febrile critically ill patients. Critical Care & Resuscitation 2011;13:194-199
  • Hicks P, Mackle D. Cause of deaths in intensive care patients within 2 years of discharge from hospital. Critical Care & Resuscitation 2010;12(2):78-82
  • Young P, Saxena M, Eastwood GM, Bellomo R, Beasley R. Fever and fever management among intensive care patients with known or suspected infection: a multicentre prospective cohort study. Critical Care & Resuscitation 2011;13(2):97-102
  • Jefferies S, Weatherall M, Young P, Eyers S, Perrin K, Beasley R. The effect of antipyretic medications on mortality in critically ill patients with infection: a systematic review & meta-analysis. Critical Care & Resuscitation 2011;13(2):125-131
2010 (4)
  • Young P, Arnold R. Intensive care triage in Australia & New Zealand. New Zealand Medical Journal 2010;123(1316):4153
  • Butt A. Nursing Care of the Chronically Critically Ill: an Exploratory Descriptive Study. Master's of Nursing Thesis, Victoria University; 2010. http://hdl.handle.net/10063/1256
  • Lawton B, Wilson L, Dinsdale R, Rose S, Brown S, Tait J, Coles C, McCaw A. Audit of severe acute maternal morbidity describing reasons for transfer and potential preventability of admissions to ICU. Australian & New Zealand Journal of Obstetrics & Gynaecology 2010;50(4):346-351
  • Jarden R, Quirke S. Improving safety & documentation in intrahospital transport - development of an intrahospital transport tool for critically ill patients. Intensive & Critical Care Nursing 2010;26(2):101-7
2009 (4)
  • Jaconelli T, Psirides A. A fulminant rash: purpura fulminans. New Zealand Medical Journal 2009;122(1293):3558
  • Psirides A, Sturland S. Withdrawal of active treatment in intensive care - what is stopped - comparison between belief & practice. Critical Care & Resuscitation 2009; 11(3):210-214
  • Jarden R. Gastric Residual Volumes in the Adult Intensive Care Patient: a Systematic Review. Master's of Nursing, Victoria University 2009. http://hdl.handle.net/10063/1188
  • Martin J, Hicks P, Norrish C, Chavan S, George C, Stow P, Hart G. Designing & implementing an Australian & New Zealand intensive care data audit study. International Journal of Health Care & Quality Assurance 2009;22(6):572-81
2008 (2)
  • Psirides A, Hicks P. Intensive Care in an unusual setting - management of pneumonia in a chimpanzee. Critical Care & Resuscitation 2008;10(1):58
  • Hicks P, Cooper DJ. The Surviving Sepsis Campaign - International guidelines for the management of severe sepsis and septic shock: 2008. An assessment by the Australian & New Zealand Intensive Care Society. Anaesthesia & Intensive Care 2008;36(2):149-151
Older (4)
  • Walker HC, Dinsdale D, Abernethy DA. Motor neuron disease presenting as postoperative respiratory failure. Anaesthesia & Intensive Care 2006 Feb;34(1):93-6
  • Ryder-Lewis M. Going home from ICU to die - a celebration of life. Nursing in Critical Care 2005;10(3):116-121
  • Ryder-Lewis M. Reliability Study of the Sedation-Agitation Scale in an Intensive Care Unit. Master's of Nursing thesis, Victoria University; 2004: http://hdl.handle.net/10063/59
  • Flabouris A. Patient referral and transportation to a regional tertiary ICU: patient demographics, severity of illness and outcome comparison with non-transported patients. Anaesthesia & Intensive Care 1999;27:385-390
ANZICS CTG Trials

Publications From ANZICS & Other Clinical Trials Groups

ANZICS Clinical Trials Group

Wellington ICU participates in many ANZICS CTG studies as well as those from other international clinical trial groups. Collaborative studies in which Wellington ICU staff were involved are listed below:

  • Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries. Russotto V et al. for the INTUBE Study Investigators. JAMA 2021;325(12):1164-1172
  • Ventilator Weaning and Discontinuation Practices for Critically Ill Patients. Burns K et al. for the Canadian Critical Care Trials Group. JAMA 2021;325(12):1173-1184
  • Erythropoietin in traumatic brain injury (EPO-TBI) - a double-blind randomised controlled trial. The EPO-TBI investigators & the ANZICS Clinical Trials Group. Lancet 2015.
  • Early Parenteral Nutrition in Critically Ill Patient With Short-term Relative Contraindications to Early Enteral Nutrition - A Randomized Controlled Trial. The Early PN Investigators of the ANZICS Clinical Trials Group. JAMA 2013; 309 (20)
  • Early Intensive Care Sedation Predicts Long-term Mortality in Ventilated Critically Ill Patients - the SPICE Study Investigators & the Australian and New Zealand Intensive Care Society Clinical Trials Group. Am J Respir Crit Care Med 2012; 186(8):724-31, October 15 2012
  • Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care - the CHEST Investigators & the Australian and New Zealand Intensive Care Society Clinical Trials Group. N Engl J Med 2012; 367:1901-1911, November 15 2012
  • Decompressive Craniectomy in Diffuse Traumatic Brain Injury - the DECRA Trial Investigators & the Australian and New Zealand Intensive Care Society Clinical Trials Group. N Engl J Med 2011; 364: 1493-1502, April 27 2011
  • Critical Care Services and 2009 H1N1 Influenza in Australia and New Zealand - the ANZIC Influenza Investigators. N Engl J Med 2009; 361: 1925-1934, November 12 2009
  • Hypoglycaemia and Risk of Death in Critically Ill Patients - the NICE-SUGAR Study Investigators. N Engl J Med 2012; 367: 1008-1118, September 20, 2012
  • Intensive versus Conventional Glucose Control in Critically Ill Patients - the NICE-SUGAR Study Investigators. N Engl J Med 2009; 360: 1283-1297, March 26 2009

Click on the blue & white 'Read' button to link to the article abstract in PubMed or the original journal where available online.

This page was last updated on Saturday, 26 October 2024 23:22:46